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    Adgrl3 adhesion G protein-coupled receptor L3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170641, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adgrl3provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor L3provided by RGD
    Primary source
    RGD:620836
    See related
    EnsemblRapid:ENSRNOG00000030149 AllianceGenome:RGD:620836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lec3; Cirl3; Lphn3; CIRL-3
    Summary
    Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Predicted to be involved in several processes, including locomotion involved in locomotory behavior; response to cocaine; and synapse organization. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 164.5), Lung (RPKM 131.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrl3 in Genome Data Viewer
    Location:
    14p21
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (26690891..27458132, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (26336320..27104060, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (28362176..29226085, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1-like Neighboring gene uncharacterized LOC108352732 Neighboring gene uncharacterized LOC134481836 Neighboring gene uncharacterized LOC108352841 Neighboring gene uncharacterized LOC134481835 Neighboring gene uncharacterized LOC134481900 Neighboring gene uncharacterized LOC134481737

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Regan SL, et al. Neurobiol Dis, 2021 Oct. PMID 34352385, Free PMC Article
    2. Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats. Regan SL, et al. ACS Chem Neurosci, 2020 Apr 15. PMID 32203648
    3. Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Regan SL, et al. Neurobiol Dis, 2019 Oct. PMID 31176715, Free PMC Article
    4. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Regan SL, et al. Genes Brain Behav, 2022 Sep. PMID 35985692, Free PMC Article
    5. LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5. O'Sullivan ML, et al. Neural Dev, 2014 Apr 17. PMID 24739570, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
      Title: Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
    2. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
      Title: A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
    3. Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
      Title: Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
    4. new Lphn3 knockout-out rat data collectively show that its disruption is significantly correlated with hyperactivity and associated striatal changes in dopamine markers.
      Title: Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in locomotion involved in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of postsynaptic specialization structure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cocaine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L3
    Names
    calcium-independent alpha-latrotoxin receptor 3
    calcium-independent alpha-latrotoxin receptor homolog 3
    latrophilin-3
    lectomedin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130822.2 → NP_570835.2  adhesion G protein-coupled receptor L3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      O88924, O88925, O88926, O88927, O88928, O88929, Q4LDM4, Q4LDM5, Q4LDM6, Q4LDM7, Q4LDM8, Q9Z173
      UniProtKB/TrEMBL
      A0A8I6GLK1
      Related
      ENSRNOP00000099227.1, ENSRNOT00000131643.1
      Conserved Domains (5) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      PLN03059
      Location:111 → 191
      PLN03059; beta-galactosidase; Provisional
      smart00303
      Location:881 → 933
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:562 → 626
      HormR; Domain present in hormone receptors
      cd16005
      Location:941 → 1207
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      26690891..27458132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272835.1 → XP_063128905.1  adhesion G protein-coupled receptor L3 isoform X20

    2. XM_063272833.1 → XP_063128903.1  adhesion G protein-coupled receptor L3 isoform X18

    3. XM_063272832.1 → XP_063128902.1  adhesion G protein-coupled receptor L3 isoform X17

    4. XM_063272834.1 → XP_063128904.1  adhesion G protein-coupled receptor L3 isoform X19

    5. XM_063272831.1 → XP_063128901.1  adhesion G protein-coupled receptor L3 isoform X13

    6. XM_063272830.1 → XP_063128900.1  adhesion G protein-coupled receptor L3 isoform X12

    7. XM_063272829.1 → XP_063128899.1  adhesion G protein-coupled receptor L3 isoform X11

    8. XM_063272828.1 → XP_063128898.1  adhesion G protein-coupled receptor L3 isoform X10

      Related
      ENSRNOP00000083229.2, ENSRNOT00000112088.2

    9. XM_063272823.1 → XP_063128893.1  adhesion G protein-coupled receptor L3 isoform X7

    10. XM_063272820.1 → XP_063128890.1  adhesion G protein-coupled receptor L3 isoform X3

    11. XM_039091582.2 → XP_038947510.1  adhesion G protein-coupled receptor L3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZV15, A6JCT5
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:863 → 915
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:557 → 621
      HormR; Domain present in hormone receptors
      cd16005
      Location:923 → 1180
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1180 → 1509
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:629 → 837
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    12. XM_063272822.1 → XP_063128892.1  adhesion G protein-coupled receptor L3 isoform X5

    13. XM_039091579.2 → XP_038947507.1  adhesion G protein-coupled receptor L3 isoform X6

      UniProtKB/TrEMBL
      A6JCT5
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:876 → 928
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:557 → 621
      HormR; Domain present in hormone receptors
      cd16005
      Location:936 → 1193
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1193 → 1522
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:629 → 850
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    14. XM_039091587.2 → XP_038947515.1  adhesion G protein-coupled receptor L3 isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZWD6, A6JCU0
      Conserved Domains (7) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:876 → 928
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:557 → 621
      HormR; Domain present in hormone receptors
      cd16005
      Location:936 → 1193
      7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1193 → 1256
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:629 → 850
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    15. XM_063272821.1 → XP_063128891.1  adhesion G protein-coupled receptor L3 isoform X4

    16. XM_039091585.2 → XP_038947513.1  adhesion G protein-coupled receptor L3 isoform X15

      UniProtKB/TrEMBL
      A6JCU0
      Conserved Domains (8) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:876 → 928
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:557 → 621
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1202 → 1265
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:629 → 850
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:938 → 963
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:936 → 1202
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    17. XM_017599059.3 → XP_017454548.1  adhesion G protein-coupled receptor L3 isoform X1

      UniProtKB/TrEMBL
      A6JCT7

    18. XM_039091584.2 → XP_038947512.1  adhesion G protein-coupled receptor L3 isoform X14

      UniProtKB/TrEMBL
      F1LRG7
      Related
      ENSRNOP00000056687.5, ENSRNOT00000059942.7
      Conserved Domains (8) summary
      smart00284
      Location:200 → 456
      OLF; Olfactomedin-like domains
      smart00303
      Location:876 → 928
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:557 → 621
      HormR; Domain present in hormone receptors
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1202 → 1309
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:629 → 850
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:938 → 963
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:936 → 1202
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    19. XM_008769970.4 → XP_008768192.1  adhesion G protein-coupled receptor L3 isoform X2

      UniProtKB/TrEMBL
      A6JCT7, D4AAL4
      Related
      ENSRNOP00000045365.6, ENSRNOT00000044659.7
      Conserved Domains (8) summary
      smart00284
      Location:205 → 461
      OLF; Olfactomedin-like domains
      smart00303
      Location:881 → 933
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:562 → 626
      HormR; Domain present in hormone receptors
      COG0531
      Location:951 → 1178
      PotE; Amino acid transporter [Amino acid transport and metabolism]
      pfam00002
      Location:941 → 1186
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:111 → 191
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1207 → 1579
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:635 → 853
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    20. XM_063272826.1 → XP_063128896.1  adhesion G protein-coupled receptor L3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZV15

    21. XM_063272818.1 → XP_063128888.1  adhesion G protein-coupled receptor L3 isoform X1

    22. XM_063272825.1 → XP_063128895.1  adhesion G protein-coupled receptor L3 isoform X7

      Related
      ENSRNOP00000039467.7, ENSRNOT00000048175.8

    23. XM_063272827.1 → XP_063128897.1  adhesion G protein-coupled receptor L3 isoform X9

      Related
      ENSRNOP00000096360.2, ENSRNOT00000100277.2

    24. XM_063272824.1 → XP_063128894.1  adhesion G protein-coupled receptor L3 isoform X7

    25. XM_063272819.1 → XP_063128889.1  adhesion G protein-coupled receptor L3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z173.1 GenPept UniProtKB/Swiss-Prot:Q9Z173

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