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    NRM nurim [ Homo sapiens (human) ]

    Gene ID: 11270, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NRMprovided by HGNC
    Official Full Name
    nurimprovided by HGNC
    Primary source
    HGNC:HGNC:8003
    See related
    Ensembl:ENSG00000137404 MIM:620017; AllianceGenome:HGNC:8003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRM29
    Summary
    The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in skin (RPKM 5.3), bone marrow (RPKM 5.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NRM in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30688049..30691420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30552255..30555626, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30655826..30659197, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene prothymosin alpha pseudogene 1 Neighboring gene chromosome 6 open reading frame 136 Neighboring gene DEAH-box helicase 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30638704-30639302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30640498-30641094 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:30642736-30642875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30649761-30650650 Neighboring gene protein phosphatase 1 regulatory subunit 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30650651-30651540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30668297-30668798 Neighboring gene ribosomal protein L7 pseudogene 4 Neighboring gene MDC1 antisense RNA 1 Neighboring gene mediator of DNA damage checkpoint 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Inner nuclear membrane proteins: functions and targeting. Holmer L, et al. Cell Mol Life Sci, 2001 Nov. PMID 11766875, Free PMC Article
    2. Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. Hofemeister H, et al. J Biol Chem, 2005 Jan 28. PMID 15542857
    3. Early sorting of inner nuclear membrane proteins is conserved. Braunagel SC, et al. Proc Natl Acad Sci U S A, 2007 May 29. PMID 17517639, Free PMC Article
    4. The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. Chen H, et al. Curr Mol Med, 2012 Dec. PMID 23092226
    5. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. Rolls MM, et al. J Cell Biol, 1999 Jul 12. PMID 10402458, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings implicate that the inner nuclear membrane protein Nurim plays an important role in the suppression of apoptosis
      Title: The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis.
    2. nurim is a polytopic protein tightly associated with the inner nuclear membrane
      Title: Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    nurim
    Names
    nuclear rim protein
    nurim (nuclear envelope membrane protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270707.2 → NP_001257636.1  nurim isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
      Source sequence(s)
      AK075509, BC039865, BU159435
      UniProtKB/TrEMBL
      B3KQU6

    2. NM_001270708.2 → NP_001257637.1  nurim isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTR and uses an alternate in-frame splice site in the coding region compared to variant 1. It terminates translation at an alternate stop codon resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AI521967, BC039865, BM917173
      UniProtKB/Swiss-Prot
      Q8IXM6
      UniProtKB/TrEMBL
      B3KQU6
      Related
      ENST00000462857.5

    3. NM_001270709.2 → NP_001257638.1  nurim isoform 4

      See identical proteins and their annotated locations for NP_001257638.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.
      Source sequence(s)
      JQ798186
      Consensus CDS
      CCDS59498.1
      UniProtKB/Swiss-Prot
      Q8IXM6
      UniProtKB/TrEMBL
      B3KQU6
      Related
      ENSP00000365602.5, ENST00000376420.9

    4. NM_001270710.2 → NP_001257639.1  nurim isoform 5

      See identical proteins and their annotated locations for NP_001257639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region compared to variant 1. The resulting isoform (5) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JQ798187
      UniProtKB/Swiss-Prot
      Q8IXM6
      UniProtKB/TrEMBL
      B3KQU6
      Related
      ENST00000474864.5

    5. NM_001384369.1 → NP_001371298.1  nurim isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL662797
      Consensus CDS
      CCDS4686.1
      UniProtKB/Swiss-Prot
      B0S7R0, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8IXM6, Q8WU45, Q9BSX3, Q9UN92
      UniProtKB/TrEMBL
      A0A1U9X845, B3KQU6
      Related
      ENSP00000365603.5, ENST00000376421.7

    6. NM_007243.3 → NP_009174.1  nurim isoform 1

      See identical proteins and their annotated locations for NP_009174.1

      Status: REVIEWED

      Source sequence(s)
      AL662797
      Consensus CDS
      CCDS4686.1
      UniProtKB/Swiss-Prot
      B0S7R0, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8IXM6, Q8WU45, Q9BSX3, Q9UN92
      UniProtKB/TrEMBL
      A0A1U9X845, B3KQU6
      Related
      ENSP00000259953.4, ENST00000259953.8

    RNA

    1. NR_073065.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI521967, BC039865, BM847576
      Related
      ENST00000470733.1

    2. NR_073066.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI521967, AK075509, AK298152
      Related
      ENST00000482141.5

    3. NR_073072.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL662797
      Related
      ENST00000444096.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30688049..30691420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418138.1 → XP_047274094.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_017010224.3 → XP_016865713.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2017556..2020927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328446.1 → XP_054184421.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054328445.1 → XP_054184420.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2167793..2171164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329730.1 → XP_054185705.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054329729.1 → XP_054185704.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1943903..1947274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330228.1 → XP_054186203.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054330227.1 → XP_054186202.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1998302..2001673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330516.1 → XP_054186491.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054330515.1 → XP_054186490.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      2032126..2035497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330763.1 → XP_054186738.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054330762.1 → XP_054186737.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1943163..1946534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331000.1 → XP_054186975.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054330999.1 → XP_054186974.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30552255..30555626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354141.1 → XP_054210116.1  nurim isoform X2

      UniProtKB/TrEMBL
      B4DP16

    2. XM_054354140.1 → XP_054210115.1  nurim isoform X1

      UniProtKB/TrEMBL
      B4DP16
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXM6.1 GenPept UniProtKB/Swiss-Prot:Q8IXM6

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