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    MSTO1 misato mitochondrial distribution and morphology regulator 1 [ Homo sapiens (human) ]

    Gene ID: 55154, updated on 27-Nov-2024

    Summary

    Official Symbol
    MSTO1provided by HGNC
    Official Full Name
    misato mitochondrial distribution and morphology regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:29678
    See related
    Ensembl:ENSG00000125459 MIM:617619; AllianceGenome:HGNC:29678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST; MMYAT; LST005
    Summary
    Involved in mitochondrion distribution. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 18.6), fat (RPKM 12.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MSTO1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155563246..155614967)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154748735..154753532)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155579961..155584758)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene RNA, U6 small nuclear 1297, pseudogene Neighboring gene POU class 5 homeobox 1 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:155469805-155470306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155484783-155485282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155499969-155500470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155515470-155515970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1817 Neighboring gene Sharpr-MPRA regulatory region 11909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155532613-155533180 Neighboring gene Sharpr-MPRA regulatory region 7926 Neighboring gene uncharacterized LOC101929703 Neighboring gene ASH1L antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155546798-155546935 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:155556739-155556902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155560641-155561220 Neighboring gene Sharpr-MPRA regulatory region 723 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155569297-155569949 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155569950-155570603 Neighboring gene claudin 6 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155578996-155579870 Neighboring gene uncharacterized LOC105371452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155579871-155580745 Neighboring gene gon-4 like pseudogene Neighboring gene death associated protein 3 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:155604951-155605710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155605711-155606471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155606472-155607231 Neighboring gene gon-4 like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
    MedGen: C4540096 OMIM: 617675 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10504, DKFZp686B1757, DKFZp686I01261

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion distribution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein misato homolog 1
    Names
    misato 1, mitochondrial distribution and morphology regulator
    misato homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256532.1NP_001243461.1  protein misato homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001243461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AF272833, AK222863, BC002535, DA807092
      UniProtKB/TrEMBL
      A8K3J5
      Conserved Domains (1) summary
      cd06060
      Location:6562
      misato; Misato segment II tubulin-like domain
    2. NM_001256533.1NP_001243462.1  protein misato homolog 1 isoform c

      See identical proteins and their annotated locations for NP_001243462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AF272833, BC002535, CR749791, DA807092
      UniProtKB/TrEMBL
      A8K3J5
      Conserved Domains (1) summary
      cd06060
      Location:6551
      misato; Misato segment II tubulin-like domain
    3. NM_001350772.1NP_001337701.1  protein misato homolog 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF272833, BC002535, CR749791, DA807092
      UniProtKB/TrEMBL
      A8K3J5
      Related
      ENSP00000357325.4, ENST00000368341.8
      Conserved Domains (1) summary
      cd06060
      Location:6552
      misato; Misato segment II tubulin-like domain
    4. NM_001350773.1NP_001337702.1  protein misato homolog 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA807092
      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    5. NM_001350774.1NP_001337703.1  protein misato homolog 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA807092
      Consensus CDS
      CCDS91070.1
      UniProtKB/TrEMBL
      A0A3B3IUD2
      Related
      ENSP00000498188.1, ENST00000649846.1
      Conserved Domains (1) summary
      cd06060
      Location:6428
      misato; Misato segment II tubulin-like domain
    6. NM_001350775.1NP_001337704.1  protein misato homolog 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BX421996, DA807092, H12094
      UniProtKB/TrEMBL
      A8K3J5
      Conserved Domains (1) summary
      cd06060
      Location:6511
      misato; Misato segment II tubulin-like domain
    7. NM_001350776.1NP_001337705.1  protein misato homolog 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BF027217, DA070565, DA807092
      UniProtKB/TrEMBL
      B4DLS9
      Conserved Domains (1) summary
      cd06060
      Location:88508
      misato; Misato segment II tubulin-like domain
    8. NM_001350777.1NP_001337706.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    9. NM_001350778.1NP_001337707.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA272145, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    10. NM_001350779.1NP_001337708.1  protein misato homolog 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BX421996, DA379275, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:11386
      misato; Misato segment II tubulin-like domain
    11. NM_001350780.1NP_001337709.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    12. NM_001350781.1NP_001337710.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, AY334564, BC002535, DA070565, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    13. NM_001350782.1NP_001337711.1  protein misato homolog 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Related
      ENSP00000513434.1, ENST00000697770.1
      Conserved Domains (1) summary
      cd06060
      Location:1385
      misato; Misato segment II tubulin-like domain
    14. NM_001350783.1NP_001337712.1  protein misato homolog 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA070565, DA272145, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:1384
      misato; Misato segment II tubulin-like domain
    15. NM_001350784.1NP_001337713.1  protein misato homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA379275, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain
    16. NM_001350785.1NP_001337714.1  protein misato homolog 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, AY334564, BC002535, DA272145, DA379275, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:7382
      misato; Misato segment II tubulin-like domain
    17. NM_001350786.1NP_001337715.1  protein misato homolog 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, BE717044, DA070565, DA272145, DA807092
      Conserved Domains (1) summary
      cl10017
      Location:1250
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    18. NM_001350787.1NP_001337716.1  protein misato homolog 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, CR749791, DA379275, DA807092
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:7371
      misato; Misato segment II tubulin-like domain
    19. NM_001350788.1NP_001337717.1  protein misato homolog 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cd06060
      Location:1333
      misato; Misato segment II tubulin-like domain
    20. NM_001350789.1NP_001337718.1  protein misato homolog 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, DA070565, DA272145, DA807092, H12094
      UniProtKB/TrEMBL
      A0A8V8TLP0
      Conserved Domains (1) summary
      cl10017
      Location:7330
      Tubulin_FtsZ_Cetz-like; Tubulin protein family of FtsZ and CetZ-like
    21. NM_018116.4NP_060586.2  protein misato homolog 1 isoform a

      See identical proteins and their annotated locations for NP_060586.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF272833, AK001366, AK222863, BX537684
      Consensus CDS
      CCDS1114.1
      UniProtKB/Swiss-Prot
      Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
      UniProtKB/TrEMBL
      A8K3J5
      Related
      ENSP00000245564.3, ENST00000245564.8
      Conserved Domains (1) summary
      cd06060
      Location:6563
      misato; Misato segment II tubulin-like domain

    RNA

    1. NR_046292.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, AK297140, AK309573, AL353807, BC002535, DA807092
    2. NR_046293.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses two alternate splice sites, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, AK309573, BC002535, DA807092
    3. NR_046294.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK056128, DA807092
      Related
      ENST00000494995.5
    4. NR_046295.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF272833, AK001366, BC002535, BX537684, DA807092
      Related
      ENST00000490743.5
    5. NR_146907.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, BC002535, DA807092
    6. NR_146908.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF272833, AK001366, AL353807, BC002535, BX421996, DA807092

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155563246..155614967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424007.1XP_047279963.1  protein misato homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
    2. XM_047424008.1XP_047279964.1  protein misato homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q53GR8, Q5CZ69, Q5T717, Q68CT6, Q7LBZ8, Q7Z3M7, Q7Z558, Q8TE05, Q9BUK6, Q9NQX2, Q9NVU4
    3. XM_047424021.1XP_047279977.1  protein misato homolog 1 isoform X3

    4. XM_047424030.1XP_047279986.1  protein misato homolog 1 isoform X4

    5. XM_047424011.1XP_047279967.1  protein misato homolog 1 isoform X2

      Related
      ENST00000483734.5
    6. XM_047424040.1XP_047279996.1  protein misato homolog 1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154748735..154753532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337366.1XP_054193341.1  protein misato homolog 1 isoform X3

    2. XM_054337372.1XP_054193347.1  protein misato homolog 1 isoform X4

    3. XM_054337364.1XP_054193339.1  protein misato homolog 1 isoform X2

    4. XM_054337371.1XP_054193346.1  protein misato homolog 1 isoform X15

    5. XM_054337368.1XP_054193343.1  protein misato homolog 1 isoform X12

    6. XM_054337369.1XP_054193344.1  protein misato homolog 1 isoform X13

    7. XM_054337370.1XP_054193345.1  protein misato homolog 1 isoform X14

    8. XM_054337360.1XP_054193335.1  protein misato homolog 1 isoform X6

    9. XM_054337361.1XP_054193336.1  protein misato homolog 1 isoform X7

    10. XM_054337362.1XP_054193337.1  protein misato homolog 1 isoform X8

    11. XM_054337367.1XP_054193342.1  protein misato homolog 1 isoform X11

    12. XM_054337363.1XP_054193338.1  protein misato homolog 1 isoform X9

    13. XM_054337365.1XP_054193340.1  protein misato homolog 1 isoform X10

    14. XM_054337374.1XP_054193349.1  protein misato homolog 1 isoform X16

    15. XM_054337373.1XP_054193348.1  protein misato homolog 1 isoform X5