Tril TLR4 interactor with leucine-rich repeats [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trilprovided by MGI
Official Full Name: TLR4 interactor with leucine-rich repeatsprovided by MGI
Primary source: MGI:MGI:1914123
See related: Ensembl:ENSMUSG00000043496 AllianceGenome:MGI:1914123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0644; 1200009O22Rik
Summary: Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Predicted to be part of lipopolysaccharide receptor complex. Predicted to be active in extracellular matrix and extracellular space. Is expressed in cerebral cortex and heart valve. Orthologous to human TRIL (TLR4 interactor with leucine rich repeats). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 26.07 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (53792453..53797810, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (53815468..53820825, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.
Title: TLR4-interactor with leucine-rich repeats (TRIL) is involved in diet-induced hypothalamic inflammation.
these data uncover TRIL as a mediator of innate immune responses within the brain, where it enhances neuronal cytokine responses to infection.
Title: TRIL is involved in cytokine production in the brain following Escherichia coli infection.
TRIL is a novel component of the TLR4 complex which may have particular relevance for the functional role of TLR4 in the brain
Title: TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipopolysaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of lipopolysaccharide receptor complex	IEA Inferred from Electronic Annotation more info
part_of lipopolysaccharide receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLR4 interactor with leucine rich repeats

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025817.4 → NP_080093.1 TLR4 interactor with leucine rich repeats precursor

See identical proteins and their annotated locations for NP_080093.1

Status: VALIDATED

Source sequence(s)

AC079130, BC059224, BY291576

Consensus CDS

CCDS51776.1

UniProtKB/Swiss-Prot

Q80TV0, Q8BKM5, Q9DBY4

Related

ENSMUSP00000116056.3, ENSMUST00000127748.5

Conserved Domains (6) summary

smart00060
Location:587 → 659

FN3; Fibronectin type 3 domain

cd00116
Location:229 → 364

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:37 → 57

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:85 → 108

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:229 → 289

LRR_8; Leucine rich repeat

cl15307
Location:359 → 406

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain