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    Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 20916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sucla2provided by MGI
    Official Full Name
    succinate-Coenzyme A ligase, ADP-forming, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1306775
    See related
    Ensembl:ENSMUSG00000022110 AllianceGenome:MGI:1306775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A-SCS; SCS-betaA; 4930547K18Rik
    Summary
    Predicted to enable succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Part of succinate-CoA ligase complex (ADP-forming). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study mitochondrial DNA depletion syndrome 5. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 50.4), testis adult (RPKM 42.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sucla2 in Genome Data Viewer
    Location:
    14 D3; 14 39.06 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73790226..73833584)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73552786..73596144)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7336 Neighboring gene STARR-positive B cell enhancer ABC_E936 Neighboring gene STARR-positive B cell enhancer ABC_E9408 Neighboring gene STARR-seq mESC enhancer starr_37120 Neighboring gene mediator complex subunit 4 Neighboring gene nudix hydrolase 15 Neighboring gene predicted gene, 41209 Neighboring gene STARR-positive B cell enhancer ABC_E3125 Neighboring gene STARR-seq mESC enhancer starr_37122 Neighboring gene predicted gene, 24540 Neighboring gene ribosomal protein S6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism. Lancaster MS, et al. Cell Rep, 2023 Oct 31. PMID 37819759, Free PMC Article
    2. Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion. Donti TR, et al. Dis Model Mech, 2014 Feb. PMID 24271779, Free PMC Article
    3. Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons. Zhao Y, et al. Sci Rep, 2017 Aug 2. PMID 28769029, Free PMC Article
    4. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Kacso G, et al. Biochem J, 2016 Oct 15. PMID 27496549, Free PMC Article
    5. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Tong Y, et al. Mol Cell, 2021 Jun 3. PMID 33991485

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
      Title: SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
    2. SCS A-beta loss mediates severe mitochondrial dysfunction including compromised OXPHOS efficiency, increased ROS generation, mtDNA depletion as well as altered mitochondrial dynamics towards fusion.
      Title: Loss of succinyl-CoA synthase ADP-forming β subunit disrupts mtDNA stability and mitochondrial dynamics in neurons.
    3. Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion.
      Title: Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.
    4. ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity
      Title: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in succinate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    part_of succinate-CoA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
    Names
    ATP-specific succinyl-CoA synthetase subunit beta
    succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
    succinyl-CoA synthetase beta-A chain
    NP_001348567.1
    NP_035636.1
    XP_006518820.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361638.1 → NP_001348567.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113198, AC155246
      Conserved Domains (1) summary
      cl25712
      Location:1 → 311
      SucC; Succinyl-CoA synthetase, beta subunit [Energy production and conversion]

    2. NM_011506.4 → NP_035636.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_035636.1

      Status: VALIDATED

      Source sequence(s)
      AC113198, AC155246
      Consensus CDS
      CCDS27271.1
      UniProtKB/Swiss-Prot
      Q3TVH1, Q8BGS6, Q9Z2I9
      UniProtKB/TrEMBL
      Q3UCC6
      Related
      ENSMUSP00000123765.2, ENSMUST00000160507.8
      Conserved Domains (3) summary
      PRK00696
      Location:55 → 445
      sucC; succinyl-CoA synthetase subunit beta; Provisional
      pfam00549
      Location:321 → 441
      Ligase_CoA; CoA-ligase
      pfam08442
      Location:55 → 262
      ATP-grasp_2; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      73790226..73833584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518757.4 → XP_006518820.1  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3UCC6
      Conserved Domains (1) summary
      PRK00696
      Location:92 → 482
      sucC; ADP-forming succinate--CoA ligase subunit beta
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2I9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2I9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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