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    5PtaseI Inositol polyphosphate-5-phosphatase type I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    5PtaseIprovided by FlyBase
    Official Full Name
    Inositol polyphosphate-5-phosphatase type Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259178
    Locus tag
    Dmel_CG42283
    See related
    AllianceGenome:FB:FBgn0259178
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5Ptasel; BcDNA:RE64196; CG31107; CG31110; CG42283; CG7613; dm5PtaseI; Dmel\CG42283; Inpp5a; IPP
    Old locus tag
    Dmel_CG31107; Dmel_CG31110
    Summary
    Enables inositol-polyphosphate 5-phosphatase activity. Involved in phosphatidylinositol metabolic process. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See 5PtaseI in Genome Data Viewer
    Location:
    96B17-96B18; 3-86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25040427..25045151, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20866149..20870873, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Smg6 Neighboring gene YTH N6-methyladenosine RNA binding protein Neighboring gene uncharacterized protein Neighboring gene baiser Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder. Fernandez A, et al. Am J Med Genet A, 2021 Jun. PMID 33720513
    2. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
    3. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    4. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
    5. Large-scale screen for modifiers of ataxin-3-derived polyglutamine-induced toxicity in Drosophila. VoSSfeldt H, et al. PLoS One, 2012. PMID 23139745, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol-polyphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inositol polyphosphate-5-phosphatase type I
    Names
    5PtaseI-PB
    5PtaseI-PC
    5PtaseI-PG
    CG42283-PB
    CG42283-PC
    CG42283-PG
    NP_001138108.1
    NP_001356900.1
    NP_733069.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25040427..25045151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170190.2 → NP_733069.1  inositol polyphosphate-5-phosphatase type I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMU3, Q8T8Q6
      Related
      FBpp0288935
      Conserved Domains (1) summary
      cd09092
      Location:11 → 382
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    2. NM_001370014.1 → NP_001356900.1  inositol polyphosphate-5-phosphatase type I, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Q1
      Conserved Domains (1) summary
      cd09092
      Location:11 → 390
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    3. NM_001144636.2 → NP_001138108.1  inositol polyphosphate-5-phosphatase type I, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Q2, Q8IGM4
      Conserved Domains (1) summary
      cd09092
      Location:11 → 390
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0Q1 B7Z0Q1
    B7Z0Q2 B7Z0Q2
    Q8IGM4 Q8IGM4
    Q8IMU3 Q8IMU3
    Q8T8Q6 Q8T8Q6

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