Kif11 kinesin family member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif11provided by MGI
Official Full Name: kinesin family member 11provided by MGI
Primary source: MGI:MGI:1098231
See related: Ensembl:ENSMUSG00000012443 AllianceGenome:MGI:1098231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eg5; Kif8; Kifl1; Knsl1
Summary: Predicted to enable plus-end-directed microtubule motor activity and protein kinase binding activity. Acts upstream of or within mitotic centrosome separation and spindle assembly. Predicted to be located in cytosol; microtubule; and spindle. Predicted to be part of protein-containing complex. Predicted to be active in mitotic spindle; nucleus; and spindle microtubule. Predicted to colocalize with spindle pole. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 30.5), liver E14 (RPKM 27.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.27 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (37364830..37410311)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (37376382..37421863)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-kappaB signaling.
Title: Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-κB signaling.
LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
Title: LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
Title: ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Title: A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
Title: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
KIF11 (kinesin-5/Eg5), which functions in spindle formation during mitosis and meiosis in oocytes and early embryos, is expressed in premeiotic germ cells (spermatogonia and spermatocytes).
Title: KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections.
Kif11 regulates excitatory synaptic transmission. Kif11 knockdown enhanced dendritic arborization, synapse number, expression of synaptophysin and Piccolo in vitro.
Title: Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology. NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites.
Title: NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization.
that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
Title: Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis.
Title: Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AJ223293 (e-PCR)
- UniSTS:163615

Kif11 (e-PCR), detects polymorphism
- UniSTS:507007

Kifl1 (e-PCR), detects polymorphism
- UniSTS:166620

Kifl1-ps (e-PCR), detects polymorphism
- UniSTS:166621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic centrosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic centrosome separation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
colocalizes_with spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF11

Names: kinesin-like 1; kinesin-related motor protein Eg5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010615.2 → NP_034745.1 kinesin-like protein KIF11

See identical proteins and their annotated locations for NP_034745.1

Status: VALIDATED

Source sequence(s)

BC060670, BY097786, CJ206639

Consensus CDS

CCDS29777.1

UniProtKB/Swiss-Prot

Q6P9P6, Q9Z1J0

Related

ENSMUSP00000012587.4, ENSMUST00000012587.4

Conserved Domains (3) summary

smart00129
Location:17 → 365

KISc; Kinesin motor, catalytic domain. ATPase

cd01364
Location:15 → 367

KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins

pfam13931
Location:915 → 1047

Microtub_bind; Kinesin-associated microtubule-binding