Trak2 trafficking protein, kinesin binding 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trak2provided by MGI
Official Full Name: trafficking protein, kinesin binding 2provided by MGI
Primary source: MGI:MGI:1918077
See related: Ensembl:ENSMUSG00000026028 AllianceGenome:MGI:1918077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GRIF1; OIP98; CALS-C; GRIF-1; Als2cr3; mKIAA0549; 2900022D04Rik; 4733401O11Rik
Summary: Predicted to enable several functions, including GABA receptor binding activity; TPR domain binding activity; and cytoskeletal protein binding activity. Predicted to be involved in several processes, including dendrite morphogenesis; negative regulation of axonogenesis; and organelle transport along microtubule. Predicted to be located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion. Is expressed in several structures, including brain; genitourinary system; liver; retina nuclear layer; and spleen. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 25.9), liver E14.5 (RPKM 25.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.3; 1 29.2 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (58939608..59013509, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (58900449..58974345, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
Title: The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

AI480836 (e-PCR)
- UniSTS:158794

RH140019 (e-PCR)
- UniSTS:222101

NoName (e-PCR)
- UniSTS:234134

AW046271 (e-PCR)
- UniSTS:178398

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	ISO Inferred from Sequence Orthology more info
enables TPR domain binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables myosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendritic transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion distribution	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trafficking kinesin-binding protein 2

Names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172406.3 → NP_765994.2 trafficking kinesin-binding protein 2

See identical proteins and their annotated locations for NP_765994.2

Status: VALIDATED

Source sequence(s)

AK036650, AK053848, BC060681, CJ116609

Consensus CDS

CCDS14980.1

UniProtKB/TrEMBL

Q6P9N8, Q8BZ57

Related

ENSMUSP00000027186.6, ENSMUST00000027186.12

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

58939608..59013509 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153623.1 → XP_036009516.1 trafficking kinesin-binding protein 2 isoform X1

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:433 → 584

Milton; Kinesin associated protein
XM_006496280.4 → XP_006496343.1 trafficking kinesin-binding protein 2 isoform X4

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein
XM_036153625.1 → XP_036009518.1 trafficking kinesin-binding protein 2 isoform X1

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:433 → 584

Milton; Kinesin associated protein
XM_036153639.1 → XP_036009532.1 trafficking kinesin-binding protein 2 isoform X7

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:24 → 288

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:349 → 500

Milton; Kinesin associated protein
XM_006496281.5 → XP_006496344.1 trafficking kinesin-binding protein 2 isoform X6

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (3) summary

cl29994
Location:694 → 734

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

pfam04849
Location:24 → 288

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:349 → 500

Milton; Kinesin associated protein
XM_036153638.1 → XP_036009531.1 trafficking kinesin-binding protein 2 isoform X5

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:24 → 307

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:368 → 519

Milton; Kinesin associated protein
XM_036153627.1 → XP_036009520.1 trafficking kinesin-binding protein 2 isoform X2

UniProtKB/TrEMBL

Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:433 → 584

Milton; Kinesin associated protein
XM_036153640.1 → XP_036009533.1 trafficking kinesin-binding protein 2 isoform X8

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:433 → 584

Milton; Kinesin associated protein
XM_030242947.2 → XP_030098807.1 trafficking kinesin-binding protein 2 isoform X3

UniProtKB/TrEMBL

Q6P9N8, Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein
XM_036153630.1 → XP_036009523.1 trafficking kinesin-binding protein 2 isoform X3

UniProtKB/TrEMBL

Q6P9N8, Q8BZ57

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein
XM_036153641.1 → XP_036009534.1 trafficking kinesin-binding protein 2 isoform X9

UniProtKB/TrEMBL

G3UYW9

Related

ENSMUSP00000134253.2, ENSMUST00000174120.2

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein
XM_006496282.4 → XP_006496345.1 trafficking kinesin-binding protein 2 isoform X9

UniProtKB/TrEMBL

G3UYW9

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:414 → 565

Milton; Kinesin associated protein
XM_036153642.1 → XP_036009535.1 trafficking kinesin-binding protein 2 isoform X10

Conserved Domains (2) summary

pfam04849
Location:24 → 288

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:349 → 500

Milton; Kinesin associated protein