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    Accsl 1-aminocyclopropane-1-carboxylate synthase (inactive)-like [ Mus musculus (house mouse) ]

    Gene ID: 381411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Accslprovided by MGI
    Official Full Name
    1-aminocyclopropane-1-carboxylate synthase (inactive)-likeprovided by MGI
    Primary source
    MGI:MGI:3584519
    See related
    Ensembl:ENSMUSG00000075023 AllianceGenome:MGI:3584519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1967
    Summary
    Predicted to enable transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCSL (1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 1.5), cerebellum adult (RPKM 0.2) and 5 other tissues See more
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    Genomic context

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    See Accsl in Genome Data Viewer
    Location:
    2 E1; 2 51.62 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93685705..93760827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93855360..93930482, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene exostosin glycosyltransferase 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93662723-93662832 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase (inactive) Neighboring gene predicted gene, 54116 Neighboring gene STARR-seq mESC enhancer starr_05168 Neighboring gene predicted gene, 39884 Neighboring gene predicted gene 1335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Yu C, et al. Cell Res, 2016 Mar. PMID 26902285, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
    Names
    1-aminocyclopropane-1-carboxylate synthase (non-functional)-like
    1-aminocyclopropane-1-carboxylate synthase homolog(non-functional)-like
    1-aminocyclopropane-1-carboxylate synthase-like protein 2
    ACC synthase-like protein 2
    novel aminotransferase class I and II domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033452.4 → NP_001028624.2  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001028624.2

      Status: VALIDATED

      Source sequence(s)
      AK135828, BM225295, CF913709
      Consensus CDS
      CCDS38183.1
      UniProtKB/Swiss-Prot
      Q3TQ30, Q3UX83
      Related
      ENSMUSP00000097281.4, ENSMUST00000099690.4
      Conserved Domains (2) summary
      cd00609
      Location:193 → 568
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PLN02607
      Location:172 → 577
      PLN02607; 1-aminocyclopropane-1-carboxylate synthase

    2. NM_001363092.1 → NP_001350021.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK163963, AL732472
      Related
      ENSMUSP00000159567.1, ENSMUST00000249087.1
      Conserved Domains (1) summary
      cl27741
      Location:100 → 515
      Aminotran_1_2; Aminotransferase class I and II

    3. NM_001363093.1 → NP_001350022.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK142866, AL732472
      UniProtKB/TrEMBL
      B9EIY1, Q3UQ29
      Related
      ENSMUST00000141561.9
      Conserved Domains (1) summary
      cl27741
      Location:9 → 352
      Aminotran_1_2; Aminotransferase class I and II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      93685705..93760827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239645.4 → XP_011237947.1  probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2 isoform X1

      Conserved Domains (1) summary
      PLN02450
      Location:156 → 571
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UX83.1 GenPept UniProtKB/Swiss-Prot:Q3UX83

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