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    Or6k8 olfactory receptor family 6 subfamily K member 8 [ Mus musculus (house mouse) ]

    Gene ID: 258715, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Or6k8provided by MGI
    Official Full Name
    olfactory receptor family 6 subfamily K member 8provided by MGI
    Primary source
    MGI:MGI:3030255
    See related
    Ensembl:ENSMUSG00000091950 AllianceGenome:MGI:3030255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olfr421; MOR105-3; Or6k8-ps1; Olfr421-ps1; Olfr422-ps1
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene appears to represent a strain-specific polymorphic pseudogene in mouse, where some strains, including the C57BL/6 reference genome strain, have a non-functional allele, while other strains have a protein-coding allele. [provided by RefSeq, Apr 2012]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
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    Genomic context

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    See Or6k8 in Genome Data Viewer
    Location:
    1 H3; 1 80.94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173979047..173980096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (174151481..174152530)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily K member 4 Neighboring gene olfactory receptor family 6 subfamily K member 3 Neighboring gene olfactory receptor family 6 subfamily K member 2 Neighboring gene STARR-seq mESC enhancer starr_03086 Neighboring gene predicted gene, 36196 Neighboring gene spectrin alpha, erythrocytic 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    2. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    3. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article
    4. A unified nomenclature for vertebrate olfactory receptors. Olender T, et al. BMC Evol Biol, 2020 Apr 15. PMID 32295537, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor family 6 subfamily K member 8
    Names
    GA_x6K02T2P20D-21002372-21001425
    GA_x6K02T2P20D-21006310-21006124
    olfactory receptor 421, pseudogene 1
    olfactory receptor 422, pseudogene 1
    olfactory receptor MOR105-3
    olfactory receptor family 6 subfamily K member 8, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146720.3 → NP_666931.3  olfactory receptor family 6 subfamily K member 8

      See identical proteins and their annotated locations for NP_666931.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the functional non-reference strain allele and encodes the full-length protein.
      Source sequence(s)
      BC119233
      UniProtKB/TrEMBL
      Q8VFZ0
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 289
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 305
      7tm_4; Olfactory receptor

    RNA

    1. NR_047667.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, non-coding) includes a premature stop codon and represents the non-functional allele, as in the C57BL/6 reference genome.
      Source sequence(s)
      AC113483
      Related
      ENSMUST00000179386.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173979047..173980096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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