Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nacc1provided by MGI
Official Full Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containingprovided by MGI
Primary source: MGI:MGI:1914080
See related: Ensembl:ENSMUSG00000001910 AllianceGenome:MGI:1914080
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nac1; Btbd14b; 2010001H03Rik; 4930511N13Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Is expressed in several structures, including blastocyst; cartilage; gut epithelium; nervous system; and otocyst. Orthologous to human NACC1 (nucleus accumbens associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 78.7), thymus adult (RPKM 50.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.02 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85397106..85414528, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84670477..84687862, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.
Title: Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.
NAC1 confines virus-specific memory formation of CD4[+] T cells through the ROCK1-mediated pathway.
Title: NAC1 confines virus-specific memory formation of CD4(+) T cells through the ROCK1-mediated pathway.
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.
Title: Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.
these results reveal the genome wide role for Nac1 in the contribution to the pluripotency circuitry and the regulation of the establishing pluripotent state.
Title: Nac1 facilitates pluripotency gene activation for establishing somatic cell reprogramming.
NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression.
Title: NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.
Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc promoter and regulates c-Myc transcription.
Title: Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc.
a sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates mouse embryonic stem cell differentiation into the alternative mesendodermal and neuroectodermal fates.
Title: Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation.
The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian cancer.
Title: Nac1 interacts with the POZ-domain transcription factor, Miz1.
NAC1 participates in the motility and differentiation of developing chondrocytes and cartilaginous tissues, and its expression is necessary to maintain normal axial patterning of murine skeleton.
Title: Loss of NAC1 expression is associated with defective bony patterning in the murine vertebral axis.
Nanog interacts with Nac1 through WNAAP to regulate the cell cycle of stem cells via the ERas/phosphatidylinositol 3-kinase/Akt pathway, but not pluripotency
Title: The C-terminal pentapeptide of Nanog tryptophan repeat domain interacts with Nac1 and regulates stem cell proliferation but not pluripotency.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleus accumbens-associated protein 1

Names: BTB (POZ) domain containing 14B; BTB/POZ domain-containing protein 14B; NAC-1; transcriptional repressor NAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025788.3 → NP_080064.3 nucleus accumbens-associated protein 1

See identical proteins and their annotated locations for NP_080064.3

Status: VALIDATED

Source sequence(s)

BC054800

Consensus CDS

CCDS22475.1

UniProtKB/Swiss-Prot

Q7TSZ8, Q80X97, Q9CZ72

Related

ENSMUSP00000001975.5, ENSMUST00000001975.6

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85397106..85414528 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531295.5 → XP_006531358.1 nucleus accumbens-associated protein 1 isoform X2

Conserved Domains (2) summary

smart01025
Location:355 → 433

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
XM_006531293.5 → XP_006531356.1 nucleus accumbens-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006531356.1

UniProtKB/Swiss-Prot

Q7TSZ8, Q80X97, Q9CZ72

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
XM_006531294.5 → XP_006531357.1 nucleus accumbens-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006531357.1

UniProtKB/Swiss-Prot

Q7TSZ8, Q80X97, Q9CZ72

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
XM_036154244.1 → XP_036010137.1 nucleus accumbens-associated protein 1 isoform X2

Conserved Domains (2) summary

smart01025
Location:355 → 433

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
XM_006531292.4 → XP_006531355.1 nucleus accumbens-associated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006531355.1

UniProtKB/Swiss-Prot

Q7TSZ8, Q80X97, Q9CZ72

Conserved Domains (2) summary

smart01025
Location:382 → 460

BEN; The BEN domain is found in diverse animal proteins

cd18290
Location:3 → 125

BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)