Foxp2 forkhead box P2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxp2provided by MGI
Official Full Name: forkhead box P2provided by MGI
Primary source: MGI:MGI:2148705
See related: Ensembl:ENSMUSG00000029563 AllianceGenome:MGI:2148705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CAG-16; D0Kist7; 2810043D05Rik
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator binding activity. Involved in cerebellar Purkinje cell differentiation; gene expression; and vocalization behavior. Acts upstream of or within several processes, including positive regulation of cell population proliferation; righting reflex; and vocal learning. Is active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Orthologous to human FOXP2 (forkhead box P2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 9.5), CNS E14 (RPKM 7.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 6.49 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (14901348..15441976)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (14901349..15441977)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.
Title: Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.
Foxp2 Is Required for Nucleus Accumbens-mediated Multifaceted Limbic Function.
Title: Foxp2 Is Required for Nucleus Accumbens-mediated Multifaceted Limbic Function.
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.
Title: Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.
FOXP2 confers oncogenic effects in prostate cancer.
Title: FOXP2 confers oncogenic effects in prostate cancer.
Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease.
Title: Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease.
Foxp2 inhibits Th9 cell differentiation and attenuates allergic airway inflammation in a mouse model of ovalbumin-induced asthma.
Title: Foxp2 inhibits Th9 cell differentiation and attenuates allergic airway inflammation in a mouse model of ovalbumin-induced asthma.
Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.
Title: Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice.
Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels.
Title: Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels.
Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression.
Title: Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression.
Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts.
Title: Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (3)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN102214 (e-PCR)
- UniSTS:427011

REN103238 (e-PCR)
- UniSTS:428035

REN102215 (e-PCR)
- UniSTS:427012

REN103240 (e-PCR)
- UniSTS:428037

REN102218 (e-PCR)
- UniSTS:427015

ECD06693 (e-PCR)
- UniSTS:287753

ECD03612 (e-PCR)
- UniSTS:284692

REN103256 (e-PCR)
- UniSTS:428053

REN103265 (e-PCR)
- UniSTS:428062

ECD01298 (e-PCR)
- UniSTS:282404

MTH1225 (e-PCR)
- UniSTS:130856

D6Mit305.2 (e-PCR), detects polymorphism
- UniSTS:130857

REN102253 (e-PCR)
- UniSTS:427050

REN102254 (e-PCR)
- UniSTS:427051

REN102255 (e-PCR)
- UniSTS:427052

ECD02857 (e-PCR)
- UniSTS:283950

REN103285 (e-PCR)
- UniSTS:428082

REN103286 (e-PCR)
- UniSTS:428083

REN103287 (e-PCR)
- UniSTS:428084

AI449000 (e-PCR)
- UniSTS:185656

REN102277 (e-PCR)
- UniSTS:427074

REN102278 (e-PCR)
- UniSTS:427075

D6Ertd588e (e-PCR), detects polymorphism
- UniSTS:167496

stSG611484 (e-PCR)
- UniSTS:449876

MARC_13931-13932:1007579490:1 (e-PCR)
- UniSTS:267613

MARC_13931-13932:1025532946:1 (e-PCR)
- UniSTS:267613

stSG611494 (e-PCR)
- UniSTS:449886

D6Mit1 (e-PCR), detects polymorphism
- UniSTS:116585

stSG611518 (e-PCR)
- UniSTS:449909

ECD04224 (e-PCR)
- UniSTS:285302

REN102585 (e-PCR)
- UniSTS:427382

stSG611519 (e-PCR)
- UniSTS:449910

stSG611520 (e-PCR)
- UniSTS:449911

stSG611521 (e-PCR)
- UniSTS:449912

ECD00361 (e-PCR)
- UniSTS:281472

REN102875 (e-PCR)
- UniSTS:427672

REN101856 (e-PCR)
- UniSTS:426653

REN101860 (e-PCR)
- UniSTS:426657

REN103407 (e-PCR)
- UniSTS:428204

REN103408 (e-PCR)
- UniSTS:428205

REN103155 (e-PCR)
- UniSTS:427952

REN103156 (e-PCR)
- UniSTS:427953

REN103413 (e-PCR)
- UniSTS:428210

REN103414 (e-PCR)
- UniSTS:428211

REN103422 (e-PCR)
- UniSTS:428219

REN103423 (e-PCR)
- UniSTS:428220

REN103424 (e-PCR)
- UniSTS:428221

REN103425 (e-PCR)
- UniSTS:428222

REN103427 (e-PCR)
- UniSTS:428224

REN103428 (e-PCR)
- UniSTS:428225

REN103429 (e-PCR)
- UniSTS:428226

REN103431 (e-PCR)
- UniSTS:428228

stSG611314 (e-PCR)
- UniSTS:449732

REN103432 (e-PCR)
- UniSTS:428229

REN103433 (e-PCR)
- UniSTS:428230

ECD00202 (e-PCR)
- UniSTS:281316

ECD02531 (e-PCR)
- UniSTS:283626

REN102194 (e-PCR)
- UniSTS:426991

ECD04612 (e-PCR)
- UniSTS:285684

BE110309 (e-PCR)
- UniSTS:245239

REN102203 (e-PCR)
- UniSTS:427000

REN102204 (e-PCR)
- UniSTS:427001

REN102207 (e-PCR)
- UniSTS:427004

D6Mit265 (e-PCR), detects polymorphism
- UniSTS:130814

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in caudate nucleus development	ISO Inferred from Sequence Orthology more info
involved_in caudate nucleus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar Purkinje cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation involved in lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate vocalization behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in putamen development	ISO Inferred from Sequence Orthology more info
involved_in putamen development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vocal learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box protein P2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286607.1 → NP_001273536.1 forkhead box protein P2 isoform 2

See identical proteins and their annotated locations for NP_001273536.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK042719, AK053022, BC058960, BC062926

Consensus CDS

CCDS71726.1

UniProtKB/TrEMBL

D3Z142

Related

ENSMUSP00000111132.2, ENSMUST00000115472.8

Conserved Domains (2) summary

cd00059
Location:482 → 554

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:320 → 387

FOXP-CC; FOXP coiled-coil domain
NM_053242.4 → NP_444472.2 forkhead box protein P2 isoform 1

See identical proteins and their annotated locations for NP_444472.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK042719, AK053022, AK082361, BC062926, CN526766

Consensus CDS

CCDS19918.1

UniProtKB/Swiss-Prot

P58463, Q6PD37, Q8C4F0, Q8R441

UniProtKB/TrEMBL

D3Z142

Related

ENSMUSP00000111137.2, ENSMUST00000115477.8

Conserved Domains (2) summary

cd00059
Location:503 → 575

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:341 → 408

FOXP-CC; FOXP coiled-coil domain
NM_212435.1 → NP_997600.1 forkhead box protein P2 isoform 1

See identical proteins and their annotated locations for NP_997600.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK042719, AK053022, BC062926

Consensus CDS

CCDS19918.1

UniProtKB/Swiss-Prot

P58463, Q6PD37, Q8C4F0, Q8R441

UniProtKB/TrEMBL

D3Z142

Related

ENSMUSP00000031545.8, ENSMUST00000031545.14

Conserved Domains (2) summary

cd00059
Location:503 → 575

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

pfam16159
Location:341 → 408

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

14901348..15441976

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165752.1 → XP_036021645.1 forkhead box protein P2 isoform X1

UniProtKB/TrEMBL

D3Z142

Conserved Domains (3) summary

COG5025
Location:502 → 733

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:367 → 434

FOXP-CC; FOXP coiled-coil domain

cd20065
Location:528 → 609

FH_FOXP2; Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2)