ewg erect wing [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ewgprovided by FlyBase
Official Full Name: erect wingprovided by FlyBase
Primary source: FLYBASE:FBgn0005427
Locus tag: Dmel_CG3114
See related: AllianceGenome:FB:FBgn0005427
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3114; Dmel\CG3114; EC3; EG:BACR37P7.7; Ewg; EWG; l(1)1Ag; l(1)DA659; l(1)EC3; l(1)EC3f; l(1)VA720; l[EC3]; NRF-1
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including adult somatic muscle development; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of canonical Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; ganglia; indirect flight muscle cell; larval muscle cell; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1A1-1A1; 1-0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (268509..279718, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (162542..173751, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that Ewg repression of Cyclin E expression is required for the arrest of myoblast proliferation and initiate myoblast fusion and terminal differentiation
Title: Spatio-temporal coordination of cell cycle exit, fusion and differentiation of adult muscle precursors by Drosophila Erect wing (Ewg).
in the adult intestine, Ebd acts independently of Ewg in physiological Wnt signaling, but cooperates with Ewg to induce the hyperactivation of Wnt target gene expression following Apc1 loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd homolog, promotes Wnt pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers
Title: Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.
Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap 'n' collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. Our observations indicate that activation of the Nrf1/Nrf2 pathway is a viable option for pharmacological intervention in SBMA and potentially other polyglutamine diseases.
Title: A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.
Mitochondrial fusion is regulated spatiotemporally by Ewg through Opa1-like during indirect flight muscles differentiation and growth.
Title: Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene.
ewg regulates mutually exclusive R8 rhodopsin expression.
Title: The neuronal transcription factor erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes.
The ELAV-binding site of D. virilis is fully functional in regulating alternative splicing of ewg intron 6 in D. melanogaster.
Title: ELAV-mediated 3'-end processing of ewg transcripts is evolutionarily conserved despite sequence degeneration of the ELAV-binding site.
Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin.
Title: Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin.
Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation
Title: Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation.
embryonic lethal, abnormal vision CG4262-PA forms a dodecameric complex on 135 nucleotides in the last ewg intron
Title: ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult somatic muscle development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: erect wing

Names: CG3114-PA; CG3114-PB; CG3114-PC; CG3114-PD; CG3114-PE; CG3114-PF; CG3114-PG; CG3114-PH; CG3114-PJ; CG3114-PK; CG3114-PL; CG3114-PM; CG3114-PN; erect wings; ewg-PA; ewg-PB; ewg-PC; ewg-PD; ewg-PE; ewg-PF; ewg-PG; ewg-PH; ewg-PJ; ewg-PK; ewg-PL; ewg-PM; ewg-PN

NP_001014707.1

non-AUG (CUG) translation initiation

NP_001014708.1

non-AUG (CUG) translation initiation

NP_001014709.1

non-AUG (CUG) translation initiation

NP_001014710.1

non-AUG (CUG) translation initiation

NP_001014711.1

non-AUG (CUG) translation initiation

NP_001014712.1

non-AUG (CUG) translation initiation

NP_001245443.1

non-AUG (CUG) translation initiation

NP_001245444.1

non-AUG (CUG) translation initiation

NP_001259092.1

non-AUG (CUG) translation initiation

NP_001259093.1

non-AUG (CUG) translation initiation

NP_001259094.1

non-AUG (CUG) translation initiation

NP_476892.4

non-AUG (CUG) translation initiation

NP_726660.3

non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

268509..279718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014708.2 → NP_001014708.1 erect wing, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014708.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24312

Conserved Domains (2) summary

pfam10492
Location:480 → 553

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001014707.2 → NP_001014707.1 erect wing, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014707.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24312

Conserved Domains (2) summary

pfam10492
Location:480 → 515

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001014712.2 → NP_001014712.1 erect wing, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014712.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24312

Conserved Domains (1) summary

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001014711.2 → NP_001014711.1 erect wing, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014711.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3R8, Q24312, Q59E73, Q59E74, Q59E75, Q59E76, Q59E77, Q8SXJ1, Q9NF76, Q9W5G8, Q9W5G9

Conserved Domains (2) summary

pfam10492
Location:634 → 707

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001014709.2 → NP_001014709.1 erect wing, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014709.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24312

Conserved Domains (2) summary

pfam10492
Location:634 → 669

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001014710.2 → NP_001014710.1 erect wing, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014710.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24312

Conserved Domains (1) summary

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_166836.2 → NP_726660.3 erect wing, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726660.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3R8, Q24312, Q59E73, Q59E74, Q59E75, Q59E76, Q59E77, Q8SXJ1, Q9NF76, Q9W5G8, Q9W5G9

Related

FBpp0088457

Conserved Domains (2) summary

pfam10492
Location:634 → 707

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001272165.1 → NP_001259094.1 erect wing, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259094.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGB3

Conserved Domains (1) summary

pfam10491
Location:145 → 317

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001272164.1 → NP_001259093.1 erect wing, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259093.1

Status: REVIEWED

UniProtKB/TrEMBL

B6IDK3, M9PGI0

Conserved Domains (2) summary

pfam10492
Location:589 → 624

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001272163.1 → NP_001259092.1 erect wing, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259092.1

Status: REVIEWED

UniProtKB/TrEMBL

B6IDK3, M9PG44

Conserved Domains (2) summary

pfam10492
Location:622 → 657

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_057544.4 → NP_476892.4 erect wing, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476892.4

Status: REVIEWED

UniProtKB/TrEMBL

B6IDK3

Related

FBpp0088456

Conserved Domains (2) summary

pfam10492
Location:634 → 669

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 344

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001258514.1 → NP_001245443.1 erect wing, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245443.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE19

Conserved Domains (2) summary

pfam10492
Location:483 → 518

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 347

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
NM_001258515.1 → NP_001245444.1 erect wing, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245444.1

Status: REVIEWED

UniProtKB/TrEMBL

B6IDK3, M9NEL5

Conserved Domains (2) summary

pfam10492
Location:637 → 672

Nrf1_activ_bdg; Nrf1 activator activation site binding domain

pfam10491
Location:145 → 347

Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1