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    HDAC11 Histone deacetylase 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HDAC11provided by FlyBase
    Official Full Name
    Histone deacetylase 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0051119
    Locus tag
    Dmel_CG31119
    See related
    AllianceGenome:FB:FBgn0051119
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31119; dHDAC11; DHDACX; Dmel\CG31119; dmHDA403; Hdac11; HdacX; HDACX
    Summary
    Predicted to enable histone deacetylase activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See HDAC11 in Genome Data Viewer
    Location:
    96B1-96B1; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24854496..24856243, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20680218..20681965, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Epidermal stripes and patches Neighboring gene uncharacterized protein Neighboring gene Nicastrin Neighboring gene Carbonic anhydrase 4 Neighboring gene pickpocket 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. Todd PK, et al. PLoS Genet, 2010 Dec 9. PMID 21170301, Free PMC Article
    2. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Pallos J, et al. Hum Mol Genet, 2008 Dec 1. PMID 18762557, Free PMC Article
    3. The Role of Histone Deacetylase 6 in Synaptic Plasticity and Memory. Perry S, et al. Cell Rep, 2017 Feb 7. PMID 28178513, Free PMC Article
    4. Role of histone deacetylases in gene regulation at nuclear lamina. Milon BC, et al. PLoS One, 2012. PMID 23226217, Free PMC Article
    5. Nuclear position and local acetyl-CoA production regulate chromatin state. Willnow P, et al. Nature, 2024 Jun. PMID 38839952, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpressing any of HDAC 3, 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X tremor ataxia syndrome.
      Title: Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase 11
    Names
    CG31119-PA
    CG31119-PB
    HDAC11-PA
    HDAC11-PB
    histone deacetylase X
    NP_001247296.1
    NP_733048.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24854496..24856243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260367.1 → NP_001247296.1  histone deacetylase 11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4I3, Q9VC26
      Conserved Domains (1) summary
      cd09993
      Location:51 → 336
      HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

    2. NM_170173.3 → NP_733048.1  histone deacetylase 11, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4I3, Q9VC26
      Related
      FBpp0084109
      Conserved Domains (1) summary
      cd09993
      Location:51 → 336
      HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC26 Q9VC26

    Gene LinkOut

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