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    DIP-iota Dpr-interacting protein iota [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIP-iotaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein iotaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031837
    Locus tag
    Dmel_CG11320
    See related
    AllianceGenome:FB:FBgn0031837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    11320; CG11320; CT31597; DIPiota; Dmel\CG11320
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DIP-iota in Genome Data Viewer
    Location:
    26F1-26F3; 2-21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6617134..6621700, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6617134..6621700, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dipeptidyl peptidase 10 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44913 Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 26F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article
    2. Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons. Wang Y, et al. Development, 2022 May 15. PMID 35502740, Free PMC Article
    3. Neuronal Wiring Receptors Dprs and DIPs Are GPI Anchored and This Modification Contributes to Their Cell Surface Organization. Lobb-Rabe M, et al. eNeuro, 2024 Feb. PMID 38233143, Free PMC Article
    4. Computational Assessment of Protein-Protein Binding Specificity within a Family of Synaptic Surface Receptors. Nandigrami P, et al. J Phys Chem B, 2022 Oct 6. PMID 35787023
    5. DIP/Dpr interactions and the evolutionary design of specificity in protein families. Sergeeva AP, et al. Nat Commun, 2020 May 1. PMID 32358559, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein iota
    Names
    CG11320-PB
    DIP-iota-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6617134..6621700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103630.2 → NP_001097100.1  Dpr-interacting protein iota [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097100.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3F0
      Conserved Domains (3) summary
      smart00408
      Location:245 → 313
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:141 → 227
      IG_like; Immunoglobulin like
      cl11960
      Location:132 → 213
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V3F0 Q4V3F0

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