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    Rbfox1 RNA-binding Fox protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39198, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbfox1provided by FlyBase
    Official Full Name
    RNA-binding Fox protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0052062
    Locus tag
    Dmel_CG32062
    See related
    AllianceGenome:FB:FBgn0052062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A2bp1; A2BP1; BcDNA:GM06073; CG14155; cg18441; CG18441; CG32062; dA2BP1; Dmel\CG32062; rbfox1; Rbox1
    Summary
    Enables DNA-binding transcription factor binding activity; mRNA 3'-UTR binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including germarium-derived oocyte differentiation; imaginal disc-derived wing vein specification; and regulation of gene expression. Located in nuclear lumen and ribonucleoprotein granule. Is expressed in several structures, including developmental compartment; epithelium; imaginal disc; muscle cell; and somatic precursor cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1); RBFOX2 (RNA binding fox-1 homolog 2); and RBFOX3 (RNA binding fox-1 homolog 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rbfox1 in Genome Data Viewer
    Location:
    67E4-67E5; 3-33 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10481412..10594012)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10474512..10587112)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 3 Neighboring gene uncharacterized protein Neighboring gene Sperm-Leucylaminopeptidase 4 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46212 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding Fox protein 1
    Names
    Ataxin-2 binding protein 1
    CG32062-PE
    CG32062-PF
    CG32062-PH
    CG32062-PI
    CG32062-PJ
    CG32062-PK
    CG32062-PL
    CG32062-PM
    CG32062-PN
    Rbfox1-PE
    Rbfox1-PF
    Rbfox1-PH
    Rbfox1-PI
    Rbfox1-PJ
    Rbfox1-PK
    Rbfox1-PL
    Rbfox1-PM
    Rbfox1-PN
    ataxin 2-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      10481412..10594012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259778.1NP_001246707.1  RNA-binding Fox protein 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFQ7
      Conserved Domains (2) summary
      COG0724
      Location:454542
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:460535
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    2. NM_001259779.1NP_001246708.1  RNA-binding Fox protein 1, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND74
      Conserved Domains (2) summary
      COG0724
      Location:388476
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:394469
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    3. NM_168412.4NP_729614.2  RNA-binding Fox protein 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729614.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT99
      Conserved Domains (2) summary
      COG0724
      Location:437525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:443518
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    4. NM_001274751.1NP_001261680.1  RNA-binding Fox protein 1, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF74
      Conserved Domains (2) summary
      COG0724
      Location:212300
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:218293
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    5. NM_168413.3NP_729615.2  RNA-binding Fox protein 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729615.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT98
      Conserved Domains (2) summary
      COG0724
      Location:437525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:443518
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    6. NM_001104102.4NP_001097572.1  RNA-binding Fox protein 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU08
      Conserved Domains (2) summary
      COG0724
      Location:371459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:377452
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    7. NM_001370003.1NP_001356980.1  RNA-binding Fox protein 1, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K632
      Conserved Domains (2) summary
      TIGR01628
      Location:373596
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12407
      Location:377452
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    8. NM_001104103.3NP_001097573.1  RNA-binding Fox protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097573.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNQ5
      Conserved Domains (2) summary
      COG0724
      Location:371459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:377452
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    9. NM_001104104.3NP_001097574.2  RNA-binding Fox protein 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNQ4
      Conserved Domains (2) summary
      COG0724
      Location:437525
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:443518
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins