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    sstn stepping stone [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sstnprovided by FlyBase
    Official Full Name
    stepping stoneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036476
    Locus tag
    Dmel_CG6945
    See related
    AllianceGenome:FB:FBgn0036476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6945; Dmel\CG6945; Sstn
    Summary
    Involved in regulation of cytoskeleton organization and regulation of plasma membrane organization. Located in centrosome and cleavage furrow. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sstn in Genome Data Viewer
    Location:
    71B4-71B4; 3-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15090823..15094719, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15083923..15087819, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Synaptotagmin beta Neighboring gene long non-coding RNA:CR43684 Neighboring gene Pericentrin-like protein Neighboring gene Odorant receptor 71a Neighboring gene long non-coding RNA:CR43973 Neighboring gene Glycyl-tRNA synthetase Neighboring gene CTP synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arf-GEF localization and function at myosin-rich adherens junctions via coiled-coil heterodimerization with an adaptor protein. Zheng S, et al. Mol Biol Cell, 2019 Dec 15. PMID 31693432, Free PMC Article
    2. Characterization of a Drosophila centrosome protein CP309 that shares homology with Kendrin and CG-NAP. Kawaguchi S, et al. Mol Biol Cell, 2004 Jan. PMID 14565985, Free PMC Article
    3. Organization and function of tension-dependent complexes at adherens junctions. Rauskolb C, et al. J Cell Sci, 2019 Apr 3. PMID 30837288, Free PMC Article
    4. Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo. Liu J, et al. Mol Biol Cell, 2015 Feb 15. PMID 25540427, Free PMC Article
    5. Application of the gene search system to screen for longevity genes in Drosophila. Seong KH, et al. Biogerontology, 2001. PMID 11708722

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sstn acts as a cytohesin adaptor that promotes Steppke activity for localized membrane cytoskeleton restraint in the syncytial Drosophila embryo.
      Title: Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in regulation of cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stepping stone
    Names
    CG6945-PA
    sstn-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15090823..15094719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140488.3 → NP_648745.1  stepping stone [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VUK7
      Related
      FBpp0075410
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUK7 Q9VUK7

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