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    Dnah12 dynein, axonemal, heavy chain 12 [ Mus musculus (house mouse) ]

    Gene ID: 110083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnah12provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 12provided by MGI
    Primary source
    MGI:MGI:107720
    See related
    Ensembl:ENSMUSG00000021879 AllianceGenome:MGI:107720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHC3; Gm74; HL19; DLP12; Gm284; Gm907; HL-19; Hdhc3; Dnahc3; Dnah12l; Dnahc12; Dnahc7c; Dnahc7l; 4921531P07Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be located in microtubule. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in choroid invagination; diencephalon roof plate; metencephalon part of 4th ventricle choroid plexus; olfactory epithelium; and pharynx epithelium. Orthologous to human DNAH12 (dynein axonemal heavy chain 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.7) and lung adult (RPKM 0.5) See more
    Orthologs
    human all
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    Genomic context

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    See Dnah12 in Genome Data Viewer
    Location:
    14 A3; 14 16.09 cM
    Exon count:
    77
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26412709..26614250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26691554..26892719)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene ARF GTPase 4 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672 Neighboring gene predicted gene, 34415 Neighboring gene STARR-seq mESC enhancer starr_36242 Neighboring gene STARR-seq mESC enhancer starr_36244 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene predicted gene, 41115 Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Neesen J, et al. Gene, 1997 Oct 24. PMID 9373155
    2. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, et al. Genomics, 1996 Aug 15. PMID 8812413
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. Single-cell transcriptomic analysis of mouse neocortical development. Loo L, et al. Nat Commun, 2019 Jan 11. PMID 30635555, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 12
    Names
    axonemal beta dynein heavy chain 12
    axonemal dynein heavy chain 12-like protein
    axonemal dynein heavy chain 7-like protein
    ciliary dynein heavy chain 12
    dynein heavy chain 12, axonemal
    dynein, axonemal, heavy chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370884.1 → NP_001357813.1  dynein axonemal heavy chain 12

      Status: VALIDATED

      Source sequence(s)
      AC121919, AC133179
      Conserved Domains (6) summary
      COG5245
      Location:891 → 3595
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:676 → 1110
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1238 → 1564
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2246 → 2506
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2896 → 3112
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3656 → 3956
      Dynein_C; Dynein heavy chain C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      26412709..26614250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316243.3 → XP_017171732.1  dynein axonemal heavy chain 12 isoform X3

      Related
      ENSMUSP00000022433.6, ENSMUST00000022433.12
      Conserved Domains (6) summary
      COG5245
      Location:891 → 3595
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:676 → 1110
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1238 → 1564
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2246 → 2506
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:2896 → 3112
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:3656 → 3956
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_017316242.2 → XP_017171731.1  dynein axonemal heavy chain 12 isoform X2

      UniProtKB/TrEMBL
      E9QPU2
      Conserved Domains (7) summary
      pfam12777
      Location:2472 → 2575
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:676 → 1110
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1238 → 1564
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:1828 → 2006
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:2199 → 2459
      AAA_8; P-loop containing dynein motor region D4
      pfam17852
      Location:1684 → 1819
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam17857
      Location:2039 → 2135
      AAA_lid_1; AAA+ lid domain

    3. XM_017316241.1 → XP_017171730.1  dynein axonemal heavy chain 12 isoform X1

      UniProtKB/TrEMBL
      E9QPU2
      Conserved Domains (8) summary
      pfam12777
      Location:2519 → 2622
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:676 → 1110
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1238 → 1564
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:1875 → 2053
      AAA_7; P-loop containing dynein motor region D3
      pfam12780
      Location:2246 → 2506
      AAA_8; P-loop containing dynein motor region D4
      pfam17852
      Location:1731 → 1866
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam17857
      Location:2086 → 2182
      AAA_lid_1; AAA+ lid domain
      cl38936
      Location:1552 → 1695
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_001781207.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V0Q1.2 GenPept UniProtKB/Swiss-Prot:Q3V0Q1

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