MAP1S microtubule associated protein 1S [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAP1Sprovided by HGNC
Official Full Name: microtubule associated protein 1Sprovided by HGNC
Primary source: HGNC:HGNC:15715
See related: Ensembl:ENSG00000130479 MIM:607573; AllianceGenome:HGNC:15715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAP8; BPY2IP1; C19orf5; VCY2IP1; VCY2IP-1
Summary: Enables DNA binding activity and cytoskeletal protein binding activity. Involved in metaphase chromosome alignment; microtubule cytoskeleton organization; and neuron projection morphogenesis. Located in several cellular components, including microtubule cytoskeleton; nuclear lumen; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis (RPKM 11.7), brain (RPKM 7.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (17719480..17734513)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (17853600..17868633)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (17830289..17845322)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S.
Title: Spermidine suppresses the activation of hepatic stellate cells to cure liver fibrosis through autophagy activator MAP1S.
RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway.
Title: RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway.
Results suggested that microtubule associated protein 1S (MAP1S) were up-regulated among Crohn's disease (CD) patients and MAP1S-related autophagy inhibits apoptosis of intestinal epithelial cells (IECs) through Wnt/beta-catenin signaling pathway which might play a vital role in the protection of intestinal mucosal barrier and inhibition the progression of CD.
Title: Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/β-catenin signaling in Crohn's disease.
Autophagy defects in the degradation of lipid droplets triggered by the MAP1S deficiency may enhance the initiation and development of ccRCC and reduce the survival of ccRCC patients.
Title: Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival.
HDAC4 destabilizes MAP1S, suppresses autophagy flux and promotes the accumulation of mHTT aggregates.
Title: Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin.
Ddata underline the key role of MAP1S as a global regulator of microbutule stability and demonstrate a new primary function of MAP1S to regulate MT dynamics at the onset of cytokinesis.
Title: MAP1S controls microtubule stability throughout the cell cycle in human cells.
results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules.
Title: Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus.
The PU.1-regulated MAP1S gene is implicated in neutrophil differentiation and autophagy control.
Title: Induction of the autophagy-associated gene MAP1S via PU.1 supports APL differentiation.
clarify roles of MAP1S in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance.
Title: Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation.
C19ORF5 distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest.
Title: Dual function microtubule- and mitochondria-associated proteins mediate mitotic cell death.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of MAP1S by shRNA inhibits HIV-1 infectivity in human PBMCs	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	MAP1A and MAP1S proteins activate HIV-1 retrograde trafficking by tethering capsids to microtubules in primary human macrophages	PubMed
	gag	MAP1A and MAP1S depletion leads to an accumulation of HIV-1 CA labelling throughout the cytoplasm, suggesting an inability both to reach the nuclear membrane and to uncoat	PubMed
	gag	MAP1A and MAP1S proteins interact with HIV-1 CA cores in primary human macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103228 (e-PCR)
- UniSTS:97560

D19S1132 (e-PCR)
- UniSTS:19924

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables DNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagy	TAS Traceable Author Statement more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring at centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion transport along microtubule	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neuron projection morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell junction	IDA Inferred from Direct Assay more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microtubule-associated protein 1S

Names: BPY2-interacting protein 1; MAP-1S; VCY2-interacting protein 1; microtubule-associated protein 8; variable charge Y chromosome 2-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308363.2 → NP_001295292.1 microtubule-associated protein 1S isoform 2

See identical proteins and their annotated locations for NP_001295292.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of an alternate start codon and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AA905204, AK294936, DB097723, DC401920

Consensus CDS

CCDS77262.1

UniProtKB/TrEMBL

A8K940

Related

ENSP00000439243.1, ENST00000544059.2

Conserved Domains (1) summary

cl23716
Location:232 → 278

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
NM_018174.6 → NP_060644.4 microtubule-associated protein 1S isoform 1

See identical proteins and their annotated locations for NP_060644.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA905204, BC007253, BC067115, BG771546, DB081409

Consensus CDS

CCDS32954.1

UniProtKB/Swiss-Prot

B4DH53, Q27QB1, Q66K74, Q6NXF1, Q8N3L8, Q8N3W5, Q8NI88, Q96H94, Q96IT4, Q96SP8, Q9BRC6, Q9H928, Q9NVK7

UniProtKB/TrEMBL

A8K940

Related

ENSP00000325313.3, ENST00000324096.9

Conserved Domains (1) summary

cl23716
Location:258 → 304

metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain