U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Tmc5 transmembrane channel-like gene family 5 [ Mus musculus (house mouse) ]

    Gene ID: 74424, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmc5provided by MGI
    Official Full Name
    transmembrane channel-like gene family 5provided by MGI
    Primary source
    MGI:MGI:1921674
    See related
    Ensembl:ENSMUSG00000030650 AllianceGenome:MGI:1921674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932443L08Rik
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be located in plasma membrane. Is expressed in sensory organ and skeleton. Orthologous to human TMC5 (transmembrane channel like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 18.1), large intestine adult (RPKM 16.3) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmc5 in Genome Data Viewer
    Location:
    7 F1- F2; 7 63.44 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118196520..118274308)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118597297..118675085)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 7 Neighboring gene RIKEN cDNA B230311B06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:125849164-125849465 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene centriolar coiled coil protein 110

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
    2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC118178

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane channel-like protein 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105252.1 → NP_001098722.1  transmembrane channel-like protein 5 isoform a

      See identical proteins and their annotated locations for NP_001098722.1

      Status: VALIDATED

      Source sequence(s)
      AC124444, AK028404, AV371065, BY777312
      Consensus CDS
      CCDS52374.1
      UniProtKB/Swiss-Prot
      Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
      Related
      ENSMUSP00000095694.5, ENSMUST00000098088.11
      Conserved Domains (1) summary
      pfam07810
      Location:686 → 791
      TMC; TMC domain

    2. NM_028930.3 → NP_083206.1  transmembrane channel-like protein 5 isoform b

      See identical proteins and their annotated locations for NP_083206.1

      Status: VALIDATED

      Source sequence(s)
      AC124444, AK016573, AK028404, AV371065, AY263159
      Consensus CDS
      CCDS21773.1
      UniProtKB/Swiss-Prot
      Q32NZ6
      Related
      ENSMUSP00000049784.8, ENSMUST00000057320.8
      Conserved Domains (1) summary
      pfam07810
      Location:481 → 576
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      118196520..118274308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241924.3 → XP_011240226.1  transmembrane channel-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011240226.1

      UniProtKB/Swiss-Prot
      Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
      Conserved Domains (1) summary
      pfam07810
      Location:686 → 791
      TMC; TMC domain

    2. XM_006508253.3 → XP_006508316.1  transmembrane channel-like protein 5 isoform X2

      Conserved Domains (1) summary
      pfam07810
      Location:679 → 784
      TMC; TMC domain

    3. XM_030243039.1 → XP_030098899.1  transmembrane channel-like protein 5 isoform X3

      Conserved Domains (1) summary
      pfam07810
      Location:365 → 470
      TMC; TMC domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32NZ6.1 GenPept UniProtKB/Swiss-Prot:Q32NZ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools