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    Tmc5 transmembrane channel-like gene family 5 [ Mus musculus (house mouse) ]

    Gene ID: 74424, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmc5provided by MGI
    Official Full Name
    transmembrane channel-like gene family 5provided by MGI
    Primary source
    MGI:MGI:1921674
    See related
    Ensembl:ENSMUSG00000030650 AllianceGenome:MGI:1921674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4932443L08Rik
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be located in plasma membrane. Is expressed in sensory organ and skeleton. Orthologous to human TMC5 (transmembrane channel like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 18.1), large intestine adult (RPKM 16.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmc5 in Genome Data Viewer
    Location:
    7 F1- F2; 7 63.44 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118196520..118274308)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118597297..118675085)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 7 Neighboring gene RIKEN cDNA B230311B06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:125849164-125849465 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene centriolar coiled coil protein 110

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General protein information

    Preferred Names
    transmembrane channel-like protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105252.1NP_001098722.1  transmembrane channel-like protein 5 isoform a

      See identical proteins and their annotated locations for NP_001098722.1

      Status: VALIDATED

      Source sequence(s)
      AC124444, AK028404, AV371065, BY777312
      Consensus CDS
      CCDS52374.1
      UniProtKB/Swiss-Prot
      Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
      Related
      ENSMUSP00000095694.5, ENSMUST00000098088.11
      Conserved Domains (1) summary
      pfam07810
      Location:686791
      TMC; TMC domain
    2. NM_028930.3NP_083206.1  transmembrane channel-like protein 5 isoform b

      See identical proteins and their annotated locations for NP_083206.1

      Status: VALIDATED

      Source sequence(s)
      AC124444, AK016573, AK028404, AV371065, AY263159
      Consensus CDS
      CCDS21773.1
      UniProtKB/Swiss-Prot
      Q32NZ6
      Related
      ENSMUSP00000049784.8, ENSMUST00000057320.8
      Conserved Domains (1) summary
      pfam07810
      Location:481576
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      118196520..118274308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241924.3XP_011240226.1  transmembrane channel-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011240226.1

      UniProtKB/Swiss-Prot
      Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
      Conserved Domains (1) summary
      pfam07810
      Location:686791
      TMC; TMC domain
    2. XM_006508253.3XP_006508316.1  transmembrane channel-like protein 5 isoform X2

      Conserved Domains (1) summary
      pfam07810
      Location:679784
      TMC; TMC domain
    3. XM_030243039.1XP_030098899.1  transmembrane channel-like protein 5 isoform X3

      Conserved Domains (1) summary
      pfam07810
      Location:365470
      TMC; TMC domain