CCT6 chaperonin-containing T-complex subunit CCT6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CCT6
Official Full Name: chaperonin-containing T-complex subunit CCT6
Primary source: SGD:S000002596
Locus tag: YDR188W
See related: AllianceGenome:SGD:S000002596; FungiDB:YDR188W; VEuPathDB:YDR188W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HTR3; TCP20; TCP6
Summary: Enables unfolded protein binding activity. Involved in protein folding. Part of chaperonin-containing T-complex. Orthologous to several human genes including CCT6A (chaperonin containing TCP1 subunit 6A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CCT6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (836421..838061)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings indicate that the eukaryotic chaperonin TRiC (or CCT) has evolved into a complex that is structurally divided into two sides-the CCT2 side and the CCT6 side-whose ATP binding and corresponding conformational transitions occur in a staggered manner.
Title: Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chaperone mediated protein folding independent of cofactor	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chaperonin-containing T-complex subunit CCT6

NP_010474.3

Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

836421..838061

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180496.3 → NP_010474.3 TPA: chaperonin-containing T-complex subunit CCT6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010474.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSH1, P39079

UniProtKB/TrEMBL

A6ZYE7, C7GN09, C8Z5A3, G2WAT7, N1PAF1

Conserved Domains (1) summary

TIGR02347
Location:2 → 542

chap_CCT_zeta; T-complex protein 1, zeta subunit