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    MCM21 Mcm21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCM21
    Official Full Name
    Mcm21p
    Primary source
    SGD:S000002726
    Locus tag
    YDR318W
    See related
    AllianceGenome:SGD:S000002726; FungiDB:YDR318W; VEuPathDB:YDR318W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CTF5
    Summary
    Involved in establishment of mitotic sister chromatid cohesion; negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination; and protein localization to chromosome, centromeric region. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MCM21 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (1103758..1104947)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Him1p Neighboring gene Yft2p Neighboring gene auxilin-like protein SWA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCM21 and MCM22, two novel genes of the yeast Saccharomyces cerevisiae are required for chromosome transmission. Poddar A, et al. Mol Microbiol, 1999 Jan. PMID 9987135
    2. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
    3. A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. Tsabar M, et al. PLoS Genet, 2016 Apr. PMID 27128635, Free PMC Article
    4. Geometric partitioning of cohesin and condensin is a consequence of chromatin loops. Lawrimore J, et al. Mol Biol Cell, 2018 Nov 1. PMID 30207827, Free PMC Article
    5. Synthetic dosage lethality. Measday V, et al. Methods Enzymol, 2002. PMID 12073321

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COMA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mcm21p
    NP_010604.4
    • Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1103758..1104947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180626.3 → NP_010604.4  TPA: Mcm21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010604.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSU9, Q06675
      UniProtKB/TrEMBL
      A6ZYR9, B3LFY0, C7GWL5, C8Z5M9, G2WB56, N1P756
      Conserved Domains (1) summary
      pfam09496
      Location:175 → 313
      CENP-O; Cenp-O kinetochore centromere component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06675.2

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