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    Chit1 chitinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289032, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chit1provided by RGD
    Official Full Name
    chitinase 1provided by RGD
    Primary source
    RGD:1305646
    See related
    EnsemblRapid:ENSRNOG00000028072 AllianceGenome:RGD:1305646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chitin binding activity and endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 45.0), Spleen (RPKM 21.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chit1 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48117886..48165645)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45565841..45613593)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (50947020..50994644)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096251 Neighboring gene fibromodulin Neighboring gene BTG anti-proliferation factor 2 Neighboring gene uncharacterized LOC102552406 Neighboring gene chitinase 3 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of rat chitotriosidase. Chen XH, et al. DNA Seq, 2008 Apr. PMID 17852345
    2. Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats. Verwer PE, et al. PLoS One, 2013. PMID 24155872, Free PMC Article
    3. Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates. Bussink AP, et al. FEBS J, 2009 Oct. PMID 19725875
    4. The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis. Raafat Ibrahim R, et al. Redox Rep, 2022 Dec. PMID 35094663, Free PMC Article
    5. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. Boot RG, et al. J Biol Chem, 2001 Mar 2. PMID 11085997

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis.
      Title: The emerging role of irisin in experimentally induced arthritis: a recent update involving HMGB1/MCP1/Chitotriosidase I-mediated necroptosis.
    2. Invasive pulmonary aspergillosis in immunocompromised rats caused a dramatic increase in chitinase activity.
      Title: Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats.
    3. Expression of cloned cDNA of chitotriosidase demonstrates that the encoded protein is secreted extracellularly and has chitinolytic activity.
      Title: Molecular cloning and characterization of rat chitotriosidase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endochitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chitotriosidase-1
    Names
    chitinase 1 (chitotriosidase)
    NP_001073157.1
    NP_001257775.1
    NP_001257776.1
    NP_001257777.1
    XP_038946364.1
    XP_038946365.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079689.2 → NP_001073157.1  chitotriosidase-1 precursor

      See identical proteins and their annotated locations for NP_001073157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (bChiV_5) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0S5V8, A6ICA4
      Related
      ENSRNOP00000070204.1, ENSRNOT00000080768.3
      Conserved Domains (2) summary
      cd02872
      Location:24 → 383
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:416 → 463
      ChtBD2; Chitin-binding domain type 2

    2. NM_001270846.1 → NP_001257775.1  chitotriosidase-1 precursor

      See identical proteins and their annotated locations for NP_001257775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (bChiV_4) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0S5V8, A6ICA4
      Conserved Domains (2) summary
      cd02872
      Location:24 → 383
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:416 → 463
      ChtBD2; Chitin-binding domain type 2

    3. NM_001270847.1 → NP_001257776.1  chitotriosidase-1 precursor

      See identical proteins and their annotated locations for NP_001257776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (bChiV_3) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0S5V8, A6ICA4
      Conserved Domains (2) summary
      cd02872
      Location:24 → 383
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:416 → 463
      ChtBD2; Chitin-binding domain type 2

    4. NM_001270848.1 → NP_001257777.1  chitotriosidase-1 precursor

      See identical proteins and their annotated locations for NP_001257777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (bChiV_2) differs in the 5' UTR compared to variant bChiV_5. All four variants encode the same protein.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0S5V8, A6ICA4
      Conserved Domains (2) summary
      cd02872
      Location:24 → 383
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:416 → 463
      ChtBD2; Chitin-binding domain type 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48117886..48165645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090437.2 → XP_038946365.1  chitotriosidase-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV32
      Related
      ENSRNOP00000096437.1, ENSRNOT00000099352.2
      Conserved Domains (1) summary
      cd02872
      Location:24 → 345
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

    2. XM_039090436.2 → XP_038946364.1  chitotriosidase-1 isoform X1

      UniProtKB/TrEMBL
      F7ER89
      Related
      ENSRNOP00000036477.6, ENSRNOT00000035658.7
      Conserved Domains (2) summary
      cd02872
      Location:14 → 373
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:406 → 453
      ChtBD2; Chitin-binding domain type 2
    Nucleotide Protein Strain
    Heading Accession and Version

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