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    sqv-8 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [ Caenorhabditis elegans ]

    Gene ID: 174517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqv-8
    Official Full Name
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
    Primary source
    WormBase:WBGene00005026
    Locus tag
    CELE_ZK1307.5
    See related
    AllianceGenome:WB:WBGene00005026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables glucuronosyltransferase activity. Involved in several processes, including chondroitin sulfate biosynthetic process; egg-laying behavior; and vulval development. Located in membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus; Larsen-like syndrome B3GAT3 type; and schizophrenia. Orthologous to several human genes including B3GAT3 (beta-1,3-glucuronyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqv-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9647878..9649367)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glucosidase 2 subunit beta Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Anaphase-promoting complex subunit 4-like WD40 domain-containing protein Neighboring gene Coiled-coil domain-containing protein 130 homolog Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Bulik DA, et al. Proc Natl Acad Sci U S A, 2000 Sep 26. PMID 11005858, Free PMC Article
    2. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927678, Free PMC Article
    3. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
    4. Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. Mizuguchi S, et al. Nature, 2003 May 22. PMID 12761550
    5. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391315, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8
    NP_496076.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9647878..9649367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063675.6 → NP_496076.1  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496076.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09363
      Conserved Domains (2) summary
      cd00218
      Location:97 → 327
      GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
      cl11433
      Location:15 → 86
      DivIC; Septum formation initiator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09363.1

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