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    LMXM_29_0340 putative KU80 protein [ Leishmania mexicana MHOM/GT/2001/U1103 ]

    Gene ID: 13451655, updated on 30-Oct-2024

    Summary

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    Gene symbol
    LMXM_29_0340
    Gene description
    putative KU80 protein
    Locus tag
    LMXM_29_0340
    Gene type
    protein coding
    RNA name
    putative KU80 protein
    RefSeq status
    PROVISIONAL
    Organism
    Leishmania mexicana MHOM/GT/2001/U1103 (strain: MHOM/GT/2001/U1103)
    Lineage
    Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania
    Orthologs
    Leishmania major all
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    Genomic context

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    See LMXM_29_0340 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    1
    Sequence:
    Chromosome: 29; NC_018333.1 (104688..107084, complement)

    Chromosome 29 - NC_018333.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene putative kinesin Neighboring gene putative endosomal integral membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_018333.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana. Poláková E, et al. PLoS Negl Trop Dis, 2021 Dec. PMID 34965251, Free PMC Article
    2. Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Rogers MB, et al. Genome Res, 2011 Dec. PMID 22038252, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.
      Title: Ku80 is involved in telomere maintenance but dispensable for genomic stability in Leishmania mexicana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Names
    putative KU80 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_018333.1 Reference assembly

      Range
      104688..107084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003877131.1 → XP_003877180.1  putative KU80 protein [Leishmania mexicana MHOM/GT/2001/U1103]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      E9B0F8
      Conserved Domains (3) summary
      cd00873
      Location:245 → 546
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      pfam08785
      Location:650 → 773
      Ku_PK_bind; Ku C terminal domain like
      cl00057
      Location:30 → 188
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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