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    glo-2 Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7 [ Caenorhabditis elegans ]

    Gene ID: 186447, updated on 2-Nov-2024

    Summary

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    Official Symbol
    glo-2
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7
    Primary source
    WormBase:WBGene00019010
    Locus tag
    CELE_F57C9.3
    See related
    AllianceGenome:WB:WBGene00019010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein homodimerization activity. Involved in endosomal transport and positive regulation of intracellular protein transport. Located in endosome. Is expressed in intestine and seam cell. Used to study Hermansky-Pudlak syndrome. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See glo-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (4836187..4844966)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene HORMA domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene C-type LECtin Neighboring gene Putative pyridoxal kinase;pyridoxal kinase Neighboring gene Rho-GAP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model. Frandsen J, et al. ACS Chem Neurosci, 2020 Feb 5. PMID 31909963
    2. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
    3. Asymmetric organelle positioning during epithelial polarization of C. elegans intestinal cells. Brandt JN, et al. Dev Biol, 2022 Jan. PMID 34597675, Free PMC Article
    4. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
    5. Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Hermann GJ, et al. Mol Biol Cell, 2005 Jul. PMID 15843430, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Biogenesis of lysosome-related organelles complex 1 subunit 6;Biogenesis of lysosome-related organelles complex 1 subunit 7
    NP_001293460.1
    • Confirmed by transcript evidence
    NP_491461.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4836187..4844966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306531.4 → NP_001293460.1  Biogenesis of lysosome-related organelles complex 1 subunit 7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      J7JQW0, O01822
      UniProtKB/TrEMBL
      M1ZK00

    2. NM_059060.3 → NP_491461.3  Biogenesis of lysosome-related organelles complex 1 subunit 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491461.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01822
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01822.5

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