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    AGER advanced glycosylation end-product specific receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 280986, updated on 1-Jan-2025

    Summary

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    Official Symbol
    AGERprovided by VGNC
    Official Full Name
    advanced glycosylation end-product specific receptorprovided by VGNC
    Primary source
    VGNC:VGNC:25724
    See related
    BGD:BT12093; Ensembl:ENSBTAG00000014420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    RAGE
    Orthologs
    human mouse all
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    Genomic context

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    See AGER in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27205663..27209270)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene notch receptor 4 Neighboring gene PBX homeobox 2 Neighboring gene ring finger protein 5 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene EGF like domain multiple 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Up-regulation in receptor for advanced glycation end-products in inflammatory circumstances in bovine coccygeal intervertebral disc specimens in vitro. Yoshida T, et al. Spine (Phila Pa 1976), 2009 Jul 1. PMID 19564763
    2. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. Schmidt AM, et al. J Biol Chem, 1992 Jul 25. PMID 1321822
    3. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages. Yan L, et al. Int J Mol Sci, 2023 Apr 10. PMID 37108174, Free PMC Article
    4. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. Neeper M, et al. J Biol Chem, 1992 Jul 25. PMID 1378843
    5. Complex tissue-specific patterns and distribution of multiple RAGE splice variants in different mammals. López-Díez R, et al. Genome Biol Evol, 2013. PMID 24273313, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
      Title: RAGE-TLR4 Crosstalk Is the Key Mechanism by Which High Glucose Enhances the Lipopolysaccharide-Induced Inflammatory Response in Primary Bovine Alveolar Macrophages.
    2. Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan content in nucleus pulposus.
      Title: Up-regulation in receptor for advanced glycation end-products in inflammatory circumstances in bovine coccygeal intervertebral disc specimens in vitro.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140817

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables laminin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    advanced glycosylation end product-specific receptor
    Names
    receptor for advanced glycosylation end products

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173982.3 → NP_776407.1  advanced glycosylation end product-specific receptor precursor

      See identical proteins and their annotated locations for NP_776407.1

      Status: PROVISIONAL

      Source sequence(s)
      M91212
      UniProtKB/Swiss-Prot
      Q28173
      UniProtKB/TrEMBL
      F1N306
      Related
      ENSBTAP00000019179.3, ENSBTAT00000019179.4
      Conserved Domains (4) summary
      smart00408
      Location:261 → 316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:254 → 328
      IG_like; Immunoglobulin like
      pfam00047
      Location:24 → 110
      ig; Immunoglobulin domain
      pfam08205
      Location:123 → 218
      C2-set_2; CD80-like C2-set immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27205663..27209270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010818312.1 → XP_010816614.1  advanced glycosylation end product-specific receptor isoform X1

      UniProtKB/TrEMBL
      F1ABP0
      Conserved Domains (4) summary
      cd00096
      Location:34 → 110
      Ig; Immunoglobulin domain
      smart00408
      Location:267 → 322
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:260 → 334
      IG_like; Immunoglobulin like
      pfam08205
      Location:123 → 218
      C2-set_2; CD80-like C2-set immunoglobulin domain

    2. XM_010818313.1 → XP_010816615.1  advanced glycosylation end product-specific receptor isoform X2

      UniProtKB/TrEMBL
      F1N306
      Conserved Domains (4) summary
      cd00096
      Location:34 → 110
      Ig; Immunoglobulin domain
      smart00408
      Location:254 → 309
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:247 → 321
      IG_like; Immunoglobulin like
      pfam08205
      Location:123 → 218
      C2-set_2; CD80-like C2-set immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28173.1 GenPept UniProtKB/Swiss-Prot:Q28173

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.