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    CASP4 caspase 4, apoptosis-related cysteine peptidase [ Bos taurus (domestic cattle) ]

    Gene ID: 338039, updated on 1-Jan-2025

    Summary

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    Gene symbol
    CASP4
    Gene description
    caspase 4, apoptosis-related cysteine peptidase
    See related
    BGD:BT22749; Ensembl:ENSBTAG00000020884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CASP13
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    Genomic context

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    See CASP4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (3250033..3269685)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene caspase 1 Neighboring gene RNA-binding protein EWS-like Neighboring gene zinc finger protein 596-like pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Evidence that caspase-13 is not a human but a bovine gene. Koenig U, et al. Biochem Biophys Res Commun, 2001 Aug 3. PMID 11478774
    2. ERICE, a novel FLICE-activatable caspase. Humke EW, et al. J Biol Chem, 1998 Jun 19. PMID 9624166
    3. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    4. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137679

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables caspase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AIM2 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of IPAF inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of NLRP3 inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase-4
    Names
    CASP-13
    CASP-4
    ERICE
    caspase 4, apoptosis-related cysteine protease
    caspase-13
    evolutionary related interleukin-1-beta-converting enzyme
    NP_788811.1
    XP_010810586.1
    XP_010810587.1
    XP_015330059.1
    XP_059730564.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176638.5 → NP_788811.1  caspase-4

      See identical proteins and their annotated locations for NP_788811.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112708
      UniProtKB/Swiss-Prot
      O75601, Q5E9C1
      UniProtKB/TrEMBL
      A0AAF6Z8F0
      Related
      ENSBTAP00000027820.4, ENSBTAT00000027820.5
      Conserved Domains (2) summary
      smart00115
      Location:126 → 375
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:5 → 85
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3250033..3269685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015474573.3 → XP_015330059.1  caspase-4 isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z8F0
      Conserved Domains (2) summary
      smart00115
      Location:194 → 443
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08325
      Location:73 → 153
      CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

    2. XM_010812285.4 → XP_010810587.1  caspase-4 isoform X3

      UniProtKB/TrEMBL
      A0AAA9SMN6, A0AAF6Z8F0
      Related
      ENSBTAP00000087618.1, ENSBTAT00000116406.1
      Conserved Domains (1) summary
      smart00115
      Location:110 → 359
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    3. XM_059874581.1 → XP_059730564.1  caspase-4 isoform X2

      UniProtKB/TrEMBL
      A0AAF6Z8F0

    4. XM_010812284.4 → XP_010810586.1  caspase-4 isoform X2

      UniProtKB/TrEMBL
      A0AAF6Z8F0
      Related
      ENSBTAP00000052549.2, ENSBTAT00000052006.4
      Conserved Domains (2) summary
      smart00115
      Location:114 → 363
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cl14633
      Location:1 → 73
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75601.1 GenPept UniProtKB/Swiss-Prot:O75601
    Q5E9C1.1 GenPept UniProtKB/Swiss-Prot:Q5E9C1

    Gene LinkOut

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