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    SCG2 secretogranin II [ Bos taurus (domestic cattle) ]

    Gene ID: 281477, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SCG2provided by VGNC
    Official Full Name
    secretogranin IIprovided by VGNC
    Primary source
    VGNC:VGNC:34332
    See related
    BGD:BT10599; EnsemblRapid:ENSBTAG00070002110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SCG2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (111768890..111774396, complement)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC112442388 Neighboring gene proteasome subunit alpha type-2-like Neighboring gene succinate dehydrogenase complex subunit C pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. PACAP stimulates the release of the secretogranin II-derived peptide EM66 from chromaffin cells. Guillemot J, et al. Ann N Y Acad Sci, 2006 Jul. PMID 16888183
    2. Sequence analysis, tissue distribution and regulation by cell depolarization, and second messengers of bovine secretogranin II (chromogranin C) mRNA. Fischer-Colbrie R, et al. J Biol Chem, 1990 Jun 5. PMID 2345170
    3. Presence of secretogranin II and high-capacity, low-affinity Ca2+ storage role in nucleoplasmic Ca2+ store vesicles. Yoo SH, et al. Biochemistry, 2007 Dec 18. PMID 18020452
    4. Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains. Leitner B, et al. Neurosci Lett, 1998 May 29. PMID 9654353
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show the localization of secretogranin II (SgII) in the nucleus, more specifically, in the IP3-sensitive nucleoplasmic Ca2+ store vesicles along with CGB and the IP3 receptors.
      Title: Presence of secretogranin II and high-capacity, low-affinity Ca2+ storage role in nucleoplasmic Ca2+ store vesicles.
    2. secretogranin II-derived peptide EM66 may act downstream of the trans-synaptic stimulation of the adrenal medulla by neurocrine factors
      Title: PACAP stimulates the release of the secretogranin II-derived peptide EM66 from chromaffin cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in eosinophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretogranin-2
    Names
    chromogranin-C
    secretogranin II (chromogranin C)
    sgII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174176.3 → NP_776601.1  secretogranin-2 precursor

      Status: PROVISIONAL

      Source sequence(s)
      J05468
      UniProtKB/Swiss-Prot
      P20616, Q3ZBY6
      Related
      ENSBTAP00070002733.1, ENSBTAT00070004845.1
      Conserved Domains (1) summary
      pfam01271
      Location:27 → 610
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      111768890..111774396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010802392.4 → XP_010800694.1  secretogranin-2 isoform X1

      UniProtKB/Swiss-Prot
      P20616, Q3ZBY6
      Conserved Domains (1) summary
      pfam01271
      Location:49 → 632
      Granin; Granin (chromogranin or secretogranin)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20616.2 GenPept UniProtKB/Swiss-Prot:P20616

    Gene LinkOut

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