U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Cdk5rap3 CDK5 regulatory subunit associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 80280, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cdk5rap3provided by MGI
    Official Full Name
    CDK5 regulatory subunit associated protein 3provided by MGI
    Primary source
    MGI:MGI:1933126
    See related
    Ensembl:ENSMUSG00000018669 AllianceGenome:MGI:1933126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C53; IC53; LZAP; HSF-27; MST016; 1810007E24Rik
    Summary
    Enables ubiquitin-like protein ligase binding activity. Involved in several processes, including definitive erythrocyte differentiation; liver development; and protein ufmylation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including brain; hemolymphoid system gland; liver; retina; and seminiferous cord. Orthologous to human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.6), genital fat pad adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdk5rap3 in Genome Data Viewer
    Location:
    11 D; 11 60.16 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96798251..96807359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96907425..96916531, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11523 Neighboring gene VISTA enhancer mm1299 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene VISTA enhancers mm876 and mm999 Neighboring gene STARR-seq mESC enhancer starr_30571 Neighboring gene predicted gene, 38961 Neighboring gene VISTA enhancer mm1675 Neighboring gene STARR-positive B cell enhancer ABC_E202 Neighboring gene predicted gene 11525 Neighboring gene proline rich 15-like Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene pyridoxine 5'-phosphate oxidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8303

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NF-kappaB binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic nuclear changes ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic nuclear changes ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in definitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G2/M transition checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2/M transition checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of reticulophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reticulophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ufmylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein ufmylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ufmylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    CDK5 regulatory subunit-associated protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308183.1NP_001295112.1  CDK5 regulatory subunit-associated protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK165494, BM211958, CK625767
      UniProtKB/TrEMBL
      Q3TSS9
      Conserved Domains (1) summary
      pfam05600
      Location:2389
      DUF773; Protein of unknown function (DUF773)
    2. NM_001363255.1NP_001350184.1  CDK5 regulatory subunit-associated protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596384
      UniProtKB/TrEMBL
      Q3TSS9
      Conserved Domains (1) summary
      pfam05600
      Location:1453
      DUF773; Protein of unknown function (DUF773)
    3. NM_001363256.1NP_001350185.1  CDK5 regulatory subunit-associated protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596384
      UniProtKB/TrEMBL
      Q3TSS9
      Conserved Domains (1) summary
      pfam05600
      Location:1453
      DUF773; Protein of unknown function (DUF773)
    4. NM_030248.2NP_084524.1  CDK5 regulatory subunit-associated protein 3 isoform 1

      See identical proteins and their annotated locations for NP_084524.1

      Status: VALIDATED

      Source sequence(s)
      AK149765, BM211958, CK625767
      Consensus CDS
      CCDS25306.1
      UniProtKB/Swiss-Prot
      Q3UE41, Q99LM2
      UniProtKB/TrEMBL
      Q3TLJ5
      Related
      ENSMUSP00000099441.5, ENSMUST00000103152.11
      Conserved Domains (1) summary
      pfam05600
      Location:5500
      DUF773; Protein of unknown function (DUF773)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96798251..96807359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534526.5XP_006534589.1  CDK5 regulatory subunit-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006534589.1

      UniProtKB/TrEMBL
      Q3TSS9
      Conserved Domains (1) summary
      pfam05600
      Location:1453
      DUF773; Protein of unknown function (DUF773)
    2. XM_011249319.2XP_011247621.1  CDK5 regulatory subunit-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011247621.1

      UniProtKB/TrEMBL
      Q3TSS9
      Conserved Domains (1) summary
      pfam05600
      Location:1453
      DUF773; Protein of unknown function (DUF773)