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    CSF3 colony stimulating factor 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 281096, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CSF3provided by VGNC
    Official Full Name
    colony stimulating factor 3provided by VGNC
    Primary source
    VGNC:VGNC:27757
    See related
    BGD:BT17910; Ensembl:ENSBTAG00000021462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CSF3 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (40329799..40332910)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene gasdermin A Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene small nucleolar RNA SNORD124 Neighboring gene mediator complex subunit 24 Neighboring gene thyroid hormone receptor alpha Neighboring gene nuclear receptor subfamily 1 group D member 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and analysis of cDNA encoding bovine granulocyte-colony stimulating factor. Heidari M, et al. Vet Immunol Immunopathol, 2000 Feb 25. PMID 10690933
    2. Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF). Lovejoy B, et al. J Mol Biol, 1993 Dec 5. PMID 7504736
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables granulocyte colony-stimulating factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    granulocyte colony-stimulating factor
    Names
    G-CSF
    colony stimulating factor 3 (granulocyte)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174028.1 → NP_776453.1  granulocyte colony-stimulating factor precursor

      See identical proteins and their annotated locations for NP_776453.1

      Status: PROVISIONAL

      Source sequence(s)
      AF092533
      UniProtKB/Swiss-Prot
      P35833, Q9TV89
      UniProtKB/TrEMBL
      A0AAF6Z8Z7
      Related
      ENSBTAP00000028610.6, ENSBTAT00000028610.7
      Conserved Domains (1) summary
      cl02473
      Location:42 → 190
      IL6; Interleukin-6/G-CSF/MGF family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40329799..40332910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010816215.3 → XP_010814517.1  granulocyte colony-stimulating factor isoform X1

      UniProtKB/TrEMBL
      A0AAF6Z8Z7
      Conserved Domains (1) summary
      cl02473
      Location:42 → 175
      IL6; Interleukin-6/G-CSF/MGF family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35833.2 GenPept UniProtKB/Swiss-Prot:P35833

    Gene LinkOut

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