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    ESRRG estrogen related receptor gamma [ Homo sapiens (human) ]

    Gene ID: 2104, updated on 10-Dec-2024

    Summary

    Official Symbol
    ESRRGprovided by HGNC
    Official Full Name
    estrogen related receptor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3474
    See related
    Ensembl:ENSG00000196482 MIM:602969; AllianceGenome:HGNC:3474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma
    Summary
    This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ESRRG in Genome Data Viewer
    Location:
    1q41
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (216503246..217137702, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (215743580..216378774, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (216676588..217311044, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216419825-216420431 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4209 Neighboring gene USH2A antisense RNA 1 Neighboring gene mitochondrial ribosomal protein S18B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:216566486-216566587 Neighboring gene uncharacterized LOC107985596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:216659268-216659830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216771579-216772306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:216773848-216774416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2536 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4286 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4347 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216913568-216914135 Neighboring gene uncharacterized LOC124904512 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:217086328-217086517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217168113-217168612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4481 Neighboring gene Sharpr-MPRA regulatory region 1545 Neighboring gene MPRA-validated peak697 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217307024-217307790 Neighboring gene Sharpr-MPRA regulatory region 11696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217309339-217310050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217310051-217310761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217311473-217312183 Neighboring gene uncharacterized LOC107985461 Neighboring gene uncharacterized LOC105372920

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
    EBI GWAS Catalog
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
    EBI GWAS Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16023, KIAA0832, DKFZp781L1617

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AF-2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    estrogen-related receptor gamma
    Names
    ERR gamma-2
    estrogen receptor-related protein 3
    nuclear receptor subfamily 3 group B member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029784.1 RefSeqGene

      Range
      419327..639505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134285.3NP_001127757.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001127757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, BX647076
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355907.2, ENST00000366940.6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. NM_001243505.2NP_001230434.1  estrogen-related receptor gamma isoform 3

      See identical proteins and their annotated locations for NP_001230434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, BM723962, BU752915
      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (1) summary
      cd06946
      Location:1205
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    3. NM_001243506.2NP_001230435.1  estrogen-related receptor gamma isoform 4

      See identical proteins and their annotated locations for NP_001230435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, AK298851, BP349857, BU752915
      UniProtKB/TrEMBL
      B7Z5E9
      Conserved Domains (2) summary
      cd06946
      Location:52271
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:133
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_001243507.2NP_001230436.1  estrogen-related receptor gamma isoform 5

      See identical proteins and their annotated locations for NP_001230436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.
      Source sequence(s)
      AB020639, AB362218, AC096634, AK131193, BU752915, DB220304
      Consensus CDS
      CCDS58060.1
      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000418629.1, ENST00000463665.5
      Conserved Domains (2) summary
      cd06946
      Location:175394
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:99156
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    5. NM_001243509.2NP_001230438.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AC096634, BU752915, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000417374.1, ENST00000493748.5
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    6. NM_001243510.3NP_001230439.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230439.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388457, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000419594.1, ENST00000493603.5
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    7. NM_001243511.3NP_001230440.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388460, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    8. NM_001243512.1NP_001230441.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AK131193, AY388458, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000419155.1, ENST00000487276.5
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    9. NM_001243513.1NP_001230442.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230442.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AY388459, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355905.2, ENST00000366938.6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    10. NM_001243514.2NP_001230443.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AC096635, AY388461, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000353108.3, ENST00000360012.7
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    11. NM_001243515.2NP_001230444.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK290945, BU752915, DA720944, DA722064
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    12. NM_001243518.2NP_001230447.1  estrogen-related receptor gamma isoform 6

      See identical proteins and their annotated locations for NP_001230447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.
      Source sequence(s)
      AB020639, BC064700, BU752915
      Consensus CDS
      CCDS58061.1
      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000355904.1, ENST00000366937.5
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    13. NM_001243519.2NP_001230448.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BC008218, BU752915, DA720944
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000375761.4, ENST00000391890.7
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    14. NM_001350122.2NP_001337051.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AC096634, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    15. NM_001350123.2NP_001337052.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    16. NM_001350124.2NP_001337053.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AL603752, BU752915, BX647076, CA397450, DA215341
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    17. NM_001350125.2NP_001337054.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450, DA096417, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    18. NM_001438.4NP_001429.2  estrogen-related receptor gamma isoform 1

      See identical proteins and their annotated locations for NP_001429.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB020639, BU752915
      Consensus CDS
      CCDS41468.1
      UniProtKB/Swiss-Prot
      A8K4I0, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, P62508, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
      UniProtKB/TrEMBL
      C0SQ93, F1D8R5
      Related
      ENSP00000386171.3, ENST00000408911.8
      Conserved Domains (2) summary
      cd06946
      Location:237456
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:122218
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    19. NM_206594.3NP_996317.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355225.3, ENST00000361525.7
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    20. NM_206595.3NP_996318.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK291028, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000352077.2, ENST00000359162.6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      216503246..217137702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000625.2XP_016856114.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. XM_047449371.1XP_047305327.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    3. XM_017000622.2XP_016856111.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    4. XM_047449402.1XP_047305358.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000500992.1, ENST00000673908.1
    5. XM_017000637.2XP_016856126.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    6. XM_017000624.3XP_016856113.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    7. XM_011509265.4XP_011507567.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    8. XM_017000621.3XP_016856110.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    9. XM_047449398.1XP_047305354.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    10. XM_047449392.1XP_047305348.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93
    11. XM_047449368.1XP_047305324.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    12. XM_047449351.1XP_047305307.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    13. XM_017000634.3XP_016856123.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    14. XM_017000631.3XP_016856120.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    15. XM_047449391.1XP_047305347.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93
    16. XM_047449362.1XP_047305318.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    17. XM_047449396.1XP_047305352.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    18. XM_047449395.1XP_047305351.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    19. XM_047449389.1XP_047305345.1  estrogen-related receptor gamma isoform X5

      UniProtKB/TrEMBL
      C0SQ93
    20. XM_047449344.1XP_047305300.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    21. XM_047449397.1XP_047305353.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    22. XM_017000632.3XP_016856121.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    23. XM_011509266.4XP_011507568.1  estrogen-related receptor gamma isoform X2

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    24. XM_047449307.1XP_047305263.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    25. XM_017000636.3XP_016856125.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    26. XM_017000623.3XP_016856112.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    27. XM_047449403.1XP_047305359.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    28. XM_047449385.1XP_047305341.1  estrogen-related receptor gamma isoform X4

      UniProtKB/TrEMBL
      C0SQ93
    29. XM_011509271.3XP_011507573.1  estrogen-related receptor gamma isoform X7

      See identical proteins and their annotated locations for XP_011507573.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:226445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:104200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    30. XM_047449390.1XP_047305346.1  estrogen-related receptor gamma isoform X6

      UniProtKB/TrEMBL
      C0SQ93
    31. XM_011509269.3XP_011507571.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507571.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    32. XM_011509268.3XP_011507570.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507570.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    33. XM_011509267.1XP_011507569.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507569.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    34. XM_047449394.1XP_047305350.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93
    35. XM_047449401.1XP_047305357.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    36. XM_047449393.1XP_047305349.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      215743580..216378774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335068.1XP_054191043.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    2. XM_054335071.1XP_054191046.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    3. XM_054335065.1XP_054191040.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    4. XM_054335064.1XP_054191039.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    5. XM_054335063.1XP_054191038.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    6. XM_054335091.1XP_054191066.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    7. XM_054335088.1XP_054191063.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    8. XM_054335067.1XP_054191042.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    9. XM_054335085.1XP_054191060.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    10. XM_054335086.1XP_054191061.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    11. XM_054335080.1XP_054191055.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    12. XM_054335083.1XP_054191058.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    13. XM_054335084.1XP_054191059.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    14. XM_054335069.1XP_054191044.1  estrogen-related receptor gamma isoform X2

      UniProtKB/TrEMBL
      C0SQ93
    15. XM_054335087.1XP_054191062.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    16. XM_054335066.1XP_054191041.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
    17. XM_054335089.1XP_054191064.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    18. XM_054335092.1XP_054191067.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    19. XM_054335074.1XP_054191049.1  estrogen-related receptor gamma isoform X4

      UniProtKB/TrEMBL
      C0SQ93
    20. XM_054335078.1XP_054191053.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93
    21. XM_054335076.1XP_054191051.1  estrogen-related receptor gamma isoform X6

      UniProtKB/TrEMBL
      C0SQ93
    22. XM_054335073.1XP_054191048.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    23. XM_054335072.1XP_054191047.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    24. XM_054335070.1XP_054191045.1  estrogen-related receptor gamma isoform X3

      UniProtKB/TrEMBL
      C0SQ93
    25. XM_054335082.1XP_054191057.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    26. XM_054335081.1XP_054191056.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    27. XM_054335075.1XP_054191050.1  estrogen-related receptor gamma isoform X5

      UniProtKB/TrEMBL
      C0SQ93
    28. XM_054335079.1XP_054191054.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93
    29. XM_054335090.1XP_054191065.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
    30. XM_054335077.1XP_054191052.1  estrogen-related receptor gamma isoform X7

      UniProtKB/TrEMBL
      C0SQ93