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    Ano7 anoctamin 7 [ Mus musculus (house mouse) ]

    Gene ID: 404545, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ano7provided by MGI
    Official Full Name
    anoctamin 7provided by MGI
    Primary source
    MGI:MGI:3052714
    See related
    Ensembl:ENSMUSG00000034107 AllianceGenome:MGI:3052714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ngep; Ngep-L; Pcanap5; Tmem16g
    Summary
    This gene encodes a member of the anoctamin family, which in mammals is comprised of 10 members. Anoctamin proteins are proposed to have eight transmembrane domains with both termini facing the cytoplasm and a C-terminal domain of unknown function. While some members have been characterized as calcium-activated chloride channels, this protein is reported to have little anion conductance activity. In humans, this protein is primarily found in prostate tissues and may serve as a target for prostate cancer immunotherapy. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in stomach adult (RPKM 32.3), colon adult (RPKM 26.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ano7 in Genome Data Viewer
    Location:
    1 D; 1 47.24 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93301518..93332026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93373796..93404304)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene microRNA 6345 Neighboring gene predicted gene, 26446 Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95362466-95362649 Neighboring gene STARR-positive B cell enhancer ABC_E1556 Neighboring gene STARR-positive B cell enhancer ABC_E4336 Neighboring gene septin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4337

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Bera TK, et al. Proc Natl Acad Sci U S A, 2004 Mar 2. PMID 14981236, Free PMC Article
    2. Evolution and functional divergence of the anoctamin family of membrane proteins. Milenkovic VM, et al. BMC Evol Biol, 2010 Oct 21. PMID 20964844, Free PMC Article
    3. Expression and function of epithelial anoctamins. Schreiber R, et al. J Biol Chem, 2010 Mar 5. PMID 20056604, Free PMC Article
    4. Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. Suzuki J, et al. J Biol Chem, 2013 May 10. PMID 23532839, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables intracellularly calcium-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly calcium-gated chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium activated galactosylceramide scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium activated phosphatidylserine scrambling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium activated phospholipid scrambling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anoctamin-7
    Names
    prostate cancer associated protein 5
    transmembrane protein 16g

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271884.1 → NP_001258813.1  anoctamin-7 isoform 2

      See identical proteins and their annotated locations for NP_001258813.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 3' coding region which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC108412, AC124669
      Consensus CDS
      CCDS78656.1
      UniProtKB/Swiss-Prot
      Q14AT5
      Related
      ENSMUSP00000050495.6, ENSMUST00000058682.11
      Conserved Domains (2) summary
      pfam04547
      Location:277 → 823
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:52 → 274
      Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. NM_207031.2 → NP_996914.1  anoctamin-7 isoform 1

      See identical proteins and their annotated locations for NP_996914.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC108412, BK004075
      Consensus CDS
      CCDS15188.1
      UniProtKB/Swiss-Prot
      Q14AT5, Q6IFT5
      Related
      ENSMUSP00000140438.2, ENSMUST00000186641.7
      Conserved Domains (2) summary
      pfam04547
      Location:277 → 823
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:52 → 274
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93301518..93332026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529733.2 → XP_006529796.1  anoctamin-7 isoform X1

      See identical proteins and their annotated locations for XP_006529796.1

      UniProtKB/Swiss-Prot
      Q14AT5, Q6IFT5
      Conserved Domains (2) summary
      pfam04547
      Location:277 → 823
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:52 → 274
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    2. XM_006529736.2 → XP_006529799.1  anoctamin-7 isoform X4

      Conserved Domains (2) summary
      pfam04547
      Location:258 → 804
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:52 → 255
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    3. XM_006529734.2 → XP_006529797.1  anoctamin-7 isoform X2

      Conserved Domains (2) summary
      pfam04547
      Location:270 → 816
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:61 → 267
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    4. XM_006529735.2 → XP_006529798.1  anoctamin-7 isoform X3

      Conserved Domains (2) summary
      pfam04547
      Location:269 → 815
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:60 → 266
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    5. XM_006529737.2 → XP_006529800.1  anoctamin-7 isoform X5

      Conserved Domains (2) summary
      pfam04547
      Location:210 → 756
      Anoctamin; Calcium-activated chloride channel
      pfam16178
      Location:42 → 207
      Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

    RNA

    1. XR_004933616.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14AT5.2 GenPept UniProtKB/Swiss-Prot:Q14AT5

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