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    Dctn3 dynactin 3 [ Mus musculus (house mouse) ]

    Gene ID: 53598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dctn3provided by MGI
    Official Full Name
    dynactin 3provided by MGI
    Primary source
    MGI:MGI:1859251
    See related
    Ensembl:ENSMUSG00000028447 AllianceGenome:MGI:1859251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p24
    Summary
    Acts upstream of or within microtubule-based process. Part of dynactin complex. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 56.9), CNS E14 (RPKM 43.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dctn3 in Genome Data Viewer
    Location:
    4 A5; 4 21.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41714798..41723213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41714798..41723163, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ciliary neurotrophic factor receptor Neighboring gene STARR-seq mESC enhancer starr_10037 Neighboring gene STARR-positive B cell enhancer ABC_E11235 Neighboring gene ribonuclease P/MRP 25 subunit-like Neighboring gene AT-rich interaction domain 3C Neighboring gene STARR-positive B cell enhancer ABC_E2689 Neighboring gene sigma non-opioid intracellular receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular characterization of the p24 dynactin light chain. Pfister KK, et al. Cell Motil Cytoskeleton, 1998. PMID 9786090
    2. Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function. Chen X, et al. Cell Biosci, 2022 Jul 6. PMID 35794642, Free PMC Article
    3. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Olthof AM, et al. Nucleic Acids Res, 2021 Apr 6. PMID 33660780, Free PMC Article
    4. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Rinschen MM, et al. Hum Mol Genet, 2016 Apr 1. PMID 26792178, Free PMC Article
    5. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within microtubule-based process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynactin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynactin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynactin subunit 3
    Names
    dynactin light chain (P24)
    dynactin light chain p24
    p24 dynactin light chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159565.1 → NP_001153037.1  dynactin subunit 3 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several in-frame segments in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform B), compared to isoform A.
      Source sequence(s)
      AK011840, AV493721, BY141790
      Consensus CDS
      CCDS51143.1
      UniProtKB/TrEMBL
      E9Q919
      Related
      ENSMUSP00000130988.2, ENSMUST00000171641.2
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 137
      Dynactin_p22; Dynactin subunit p22

    2. NM_016890.4 → NP_058586.3  dynactin subunit 3 isoform A

      See identical proteins and their annotated locations for NP_058586.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AK011840, BY141790
      Consensus CDS
      CCDS18069.1
      UniProtKB/Swiss-Prot
      Q9CR43, Q9D039, Q9Z0Y1
      Related
      ENSMUSP00000030158.5, ENSMUST00000030158.11
      Conserved Domains (1) summary
      pfam07426
      Location:10 → 170
      Dynactin_p22; Dynactin subunit p22

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41714798..41723213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164239.1 → XP_036020132.1  dynactin subunit 3 isoform X1

      Conserved Domains (1) summary
      pfam07426
      Location:10 → 117
      Dynactin_p22; Dynactin subunit p22
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0Y1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0Y1

    Gene LinkOut

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