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    Tlk Tousled-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318206, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tlkprovided by FlyBase
    Official Full Name
    Tousled-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283657
    Locus tag
    Dmel_CG34412
    See related
    AllianceGenome:FB:FBgn0283657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK
    Old locus tag
    CG32781; CG32782; Dmel_CG32781; Dmel_CG32782
    Summary
    Enables protein serine/threonine kinase activity. Involved in chromatin organization; chromosome segregation; and post-translational protein modification. Located in heterochromatin and nucleus. Is expressed in several structures, including adult brain cell body rind; adult visual projection neurons; female germline cell; follicle cell; and lobula. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tlk in Genome Data Viewer
    Location:
    3E6-3F1; 1-4 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3720007..3789770)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3614040..3683803)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45102 Neighboring gene Ras-like protein A Neighboring gene mir-4962 stem loop Neighboring gene long non-coding RNA:CR44117 Neighboring gene Hsc/Hsp70-interacting protein related Neighboring gene Circadianly Regulated Gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of cell morphogenesis by tousled-like kinase in the Drosophila follicle cell. Yeh TH, et al. Dev Dyn, 2015 Jul. PMID 25981356
    2. Transcription elongation: TLKing to chromatin? Blackwell TK, et al. Curr Biol, 2003 Dec 2. PMID 14654017
    3. Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions. Carrera P, et al. Genes Dev, 2003 Oct 15. PMID 14561777, Free PMC Article
    4. Unique genetic signatures of local adaptation over space and time for diapause, an ecologically relevant complex trait, in Drosophila melanogaster. Erickson PA, et al. PLoS Genet, 2020 Nov. PMID 33216740, Free PMC Article
    5. mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila. Li HH, et al. J Biomed Sci, 2009 Jun 1. PMID 19486529, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactive Tlk associating with Tak1 increases p38 MAPK activity to prolong the G2 phase.
      Title: Inactive Tlk associating with Tak1 increases p38 MAPK activity to prolong the G2 phase.
    2. Here we report a limited RNAi screen for nuclear proteins required for border cell migration, which revealed that the gene encoding Tousled-like kinase (Tlk) is required in polar cells for Upd expression without affecting polar cell fate.
      Title: Tousled-like kinase regulates cytokine-mediated communication between cooperating cell types during collective border cell migration.
    3. double knockdown of tlk and atg2 by RNAi did not have a synergistic effect. These results suggested that ATG2 may function downstream of TLK. In addition to a role in development, tlk and atg2 RNAi could rescue calcium overload-induced cell death
      Title: Tousled-like kinase mediated a new type of cell death pathway in Drosophila.
    4. data suggest a novel role of Tlk in maintaining cell morphology, possibly through modulating the cytoskeleton.
      Title: Modulation of cell morphogenesis by tousled-like kinase in the Drosophila follicle cell.
    5. Drosophila splicing factor P element Somatic Inhibitor (PSI) is phosphorylated at at least two different sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk).
      Title: The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase.
    6. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.
      Title: Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.
    7. mars and tlk function in parallel and a balance between mars activity and tlk activity is required for cells to progress through mitosis correctly, thus ensuring chromosome fidelity
      Title: mars and tousled-like kinase act in parallel to ensure chromosome fidelity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 3726818-3727384 mobile_element_type = transposon:FB{}43

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tousled-like kinase
    Names
    BEST:GH17330
    CG34412-PB
    CG34412-PC
    CG34412-PE
    CG34412-PF
    CG34412-PG
    CG34412-PH
    CG34412-PI
    CG34412-PJ
    CG34412-PK
    CG34412-PL
    CG34412-PM
    CG34412-PN
    CG34412-PO
    CG34412-PP
    Tlk-PB
    Tlk-PC
    Tlk-PE
    Tlk-PF
    Tlk-PG
    Tlk-PH
    Tlk-PI
    Tlk-PJ
    Tlk-PK
    Tlk-PL
    Tlk-PM
    Tlk-PN
    Tlk-PO
    Tlk-PP
    tousled like kinase
    tousled-like kinase
    NP_001096873.1
    NP_001138152.1
    NP_001138153.1
    NP_001138154.1
    NP_001138155.1
    NP_001162655.1
    NP_001259220.1
    NP_001259221.1
    NP_001259222.1
    NP_001284843.1
    NP_001368971.1
    NP_001401053.1
    NP_570073.3
    NP_996343.5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3720007..3789770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144680.3 → NP_001138152.1  Tousled-like kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R23, Q9U4G7, Q9W4Q3, Q9W4Q4
      Conserved Domains (2) summary
      smart00220
      Location:938 → 1206
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:938 → 1205
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    2. NM_001382078.1 → NP_001368971.1  Tousled-like kinase, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EF15, Q29R23
      Conserved Domains (2) summary
      cd13990
      Location:938 → 1205
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase
      pfam17380
      Location:560 → 696
      DUF5401; Family of unknown function (DUF5401)

    3. NM_001414088.1 → NP_001401053.1  Tousled-like kinase, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R23

    4. NM_001144682.2 → NP_001138154.1  Tousled-like kinase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R23, Q9U4G7, Q9W4Q3, Q9W4Q4
      Conserved Domains (2) summary
      smart00220
      Location:938 → 1206
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:938 → 1205
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    5. NM_001272292.1 → NP_001259221.1  Tousled-like kinase, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDQ2
      Conserved Domains (2) summary
      smart00220
      Location:683 → 951
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:683 → 950
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    6. NM_001169184.2 → NP_001162655.1  Tousled-like kinase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R23, Q9U4G7, Q9W4Q3, Q9W4Q4
      Conserved Domains (2) summary
      smart00220
      Location:938 → 1206
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:938 → 1205
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    7. NM_206620.6 → NP_996343.5  Tousled-like kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996343.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMJ2, Q1RL19
      Conserved Domains (2) summary
      smart00220
      Location:927 → 1195
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:927 → 1194
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    8. NM_001272291.1 → NP_001259220.1  Tousled-like kinase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259220.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIZ6, Q29R23
      Conserved Domains (2) summary
      smart00220
      Location:937 → 1205
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:937 → 1204
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    9. NM_001103403.1 → NP_001096873.1  Tousled-like kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096873.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R23, Q8IRT8
      Conserved Domains (2) summary
      smart00220
      Location:1135 → 1403
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:1135 → 1402
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    10. NM_001297914.1 → NP_001284843.1  Tousled-like kinase, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z120, Q29R23
      Conserved Domains (2) summary
      smart00220
      Location:914 → 1182
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:914 → 1181
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    11. NM_001272293.1 → NP_001259222.1  Tousled-like kinase, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z120, Q29R23
      Conserved Domains (2) summary
      smart00220
      Location:914 → 1182
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:914 → 1181
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    12. NM_001144681.3 → NP_001138153.1  Tousled-like kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ82, B7Z126
      Conserved Domains (2) summary
      smart00220
      Location:1161 → 1429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:1161 → 1428
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    13. NM_001144683.1 → NP_001138155.1  Tousled-like kinase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z120, Q29R23
      Conserved Domains (2) summary
      smart00220
      Location:914 → 1182
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:914 → 1181
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase

    14. NM_130717.5 → NP_570073.3  Tousled-like kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570073.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMJ2, Q8IRT7
      Conserved Domains (2) summary
      smart00220
      Location:926 → 1194
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13990
      Location:926 → 1193
      STKc_TLK; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EF15 A0A6H2EF15
    B7Z120 B7Z120
    B7Z126 B7Z126
    M9PDQ2 M9PDQ2
    M9PIZ6 M9PIZ6
    Q1RL19 Q1RL19
    Q8IRT7 Q8IRT7
    Q8IRT8 Q8IRT8
    Q9W4Q4 Q9W4Q4

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