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    Traf-like TNF-receptor-associated factor-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Traf-likeprovided by FlyBase
    Official Full Name
    TNF-receptor-associated factor-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030748
    Locus tag
    Dmel_CG4394
    See related
    AllianceGenome:FB:FBgn0030748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4394; Dmel\CG4394; dTRAF3; Traf-related; Traf3; TRAF3
    Summary
    Involved in positive regulation of lipophagy. Predicted to be active in cytoplasm. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval garland cell; garland cell primordium; and gut section. Human ortholog(s) of this gene implicated in brain disease. Orthologous to several human genes including TRAF1 (TNF receptor associated factor 1); TRAF2 (TNF receptor associated factor 2); and TRAF3 (TNF receptor associated factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Traf-like in Genome Data Viewer
    Location:
    14C4-14C4; 1-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16415046..16417585)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16309079..16311618)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene meiotic 41 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Annexin B11 Neighboring gene hangover Neighboring gene Cell division cycle 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Grech A, et al. Mol Immunol, 2000 Aug-Sep. PMID 11275257
    2. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Wu H, et al. Bioessays, 2003 Nov. PMID 14579250
    3. Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis. Colombani J, et al. FEBS Lett, 2023 Oct. PMID 37567762
    4. A heterotrimeric death domain complex in Toll signaling. Sun H, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12351681, Free PMC Article
    5. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TNF-receptor-associated factor-like
    Names
    CG4394-PA
    CG4394-PB
    CG4394-PC
    CG4394-PD
    CG4394-PE
    CG4394-PF
    CG4394-PG
    Traf-like-PA
    Traf-like-PB
    Traf-like-PC
    Traf-like-PD
    Traf-like-PE
    Traf-like-PF
    Traf-like-PG
    Traf3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16415046..16417585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132898.4 → NP_573126.1  TNF-receptor-associated factor-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960H6
      Related
      FBpp0074049
      Conserved Domains (2) summary
      cd00270
      Location:312 → 451
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
      pfam15965
      Location:30 → 66
      zf-TRAF_2; TRAF-like zinc-finger

    2. NM_167517.3 → NP_727976.1  TNF-receptor-associated factor-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727976.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IR14
      Related
      FBpp0074051
      Conserved Domains (2) summary
      cd00270
      Location:334 → 473
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
      pfam15965
      Location:54 → 88
      zf-TRAF_2; TRAF-like zinc-finger

    3. NM_001258785.2 → NP_001245714.1  TNF-receptor-associated factor-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG5
      Conserved Domains (1) summary
      cd00270
      Location:255 → 394
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...

    4. NM_001272683.1 → NP_001259612.1  TNF-receptor-associated factor-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG5
      Conserved Domains (1) summary
      cd00270
      Location:255 → 394
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...

    5. NM_001272684.1 → NP_001259613.1  TNF-receptor-associated factor-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG5
      Conserved Domains (1) summary
      cd00270
      Location:255 → 394
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...

    6. NM_001258784.2 → NP_001245713.1  TNF-receptor-associated factor-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG5
      Conserved Domains (1) summary
      cd00270
      Location:255 → 394
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...

    7. NM_167518.3 → NP_727977.1  TNF-receptor-associated factor-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXG5
      Related
      FBpp0074050
      Conserved Domains (1) summary
      cd00270
      Location:255 → 394
      MATH_TRAF_C; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link cell surface TNFRs and receptors of the interleukin-1/Toll-like family to downstream kinase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR14 Q8IR14
    Q960H6 Q960H6
    Q9VXG5 Q9VXG5

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