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    CG14618 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14618provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031189
    Locus tag
    Dmel_CG14618
    See related
    AllianceGenome:FB:FBgn0031189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14618
    Summary
    Enables tRNA (guanosine(9)-N1)-methyltransferase activity. Involved in cellular response to heat; positive regulation of 3'-UTR-mediated mRNA stabilization; and tRNA N1-guanine methylation. Located in chromatin. Is active in nucleolus. Is expressed in embryonic/larval midgut; larval muscle system; and organism. Orthologous to human TRMT10A (tRNA methyltransferase 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14618 in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22473698..22474998)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21875534..21876834)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene touch insensitive larva B Neighboring gene wings apart Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43493 Neighboring gene Centriolar coiled coil protein 110kDa Neighboring gene lethal (1) G0196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development. Morriss GR, et al. Genetics, 2013 Nov. PMID 24026097, Free PMC Article
    2. Non-random genomic integration - an intrinsic property of retrogenes in Drosophila? Metta M, et al. BMC Evol Biol, 2010 Apr 28. PMID 20426838, Free PMC Article
    3. dTrmt10A impacts Hsp70 chaperone m(6)A levels and the stress response in the Drosophila brain. Perlegos AE, et al. Sci Rep, 2023 Dec 28. PMID 38155219, Free PMC Article
    4. Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster. Harbison ST, et al. Behav Genet, 2019 Jan. PMID 30341464, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanosine(9)-N1)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (guanosine(9)-N1)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N1-guanine methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14618-PA
    NP_608464.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22473698..22474998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134620.4 → NP_608464.1  uncharacterized protein Dmel_CG14618 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR56
      Related
      FBpp0077043
      Conserved Domains (1) summary
      pfam01746
      Location:105 → 271
      tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR56.1 Q9VR56

    Gene LinkOut

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