tub tube [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tubprovided by FlyBase
Official Full Name: tubeprovided by FlyBase
Primary source: FLYBASE:FBgn0003882
Locus tag: Dmel_CG10520
See related: AllianceGenome:FB:FBgn0003882
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10520; Dmel\CG10520; Tube; TUBE
Summary: Enables protein domain specific binding activity and protein tyrosine kinase binding activity. Involved in several processes, including Toll signaling pathway; larval somatic muscle development; and positive regulation of antifungal peptide production. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in germline cell; oocyte; organism; pole plasm; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82A5-82A5; 3-47.1 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4387742..4389813)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (213464..215535)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle.
Title: Assembly of oligomeric death domain complexes during Toll receptor signaling.
A genetic analysis was made of tub to larval hemocyte concentration and the egg encapsulation response.
Title: Genetic analysis of contributions of dorsal group and JAK-Stat92E pathway genes to larval hemocyte concentration and the egg encapsulation response in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1539 (e-PCR)
- UniSTS:18611

Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Toll signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Toll signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in determination of dorsal/ventral asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte proliferation	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of antifungal peptide production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of antifungal peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fungus	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed