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    Nep2 Neprilysin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nep2provided by FlyBase
    Official Full Name
    Neprilysin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0027570
    Locus tag
    Dmel_CG9761
    See related
    AllianceGenome:FB:FBgn0027570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH07643; CG9761; Dmel\CG9761; DmNEP2; dNEP2; nep2; NEP2
    Summary
    Enables metalloendopeptidase activity. Involved in proteolysis and sperm competition. Located in extracellular space. Is expressed in several structures, including adult brain; epithelium; follicle cell; synaptic neuropil domain; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nep2 in Genome Data Viewer
    Location:
    82D2-82D2; 3-47.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4719458..4731878, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (545180..557600, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit f1 Neighboring gene long non-coding RNA:CR44923 Neighboring gene antisense RNA:CR46137 Neighboring gene transforming acidic coiled-coil protein Neighboring gene mir-9384 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2. Bland ND, et al. Peptides, 2009 Mar. PMID 19038301
    2. Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster. Bland ND, et al. Peptides, 2007 Jan. PMID 17157960
    3. Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function. Thomas JE, et al. Biochem J, 2005 Mar 1. PMID 15554877, Free PMC Article
    4. Impact of nano-conjugate on Drosophila for early diagnosis of Alzheimer's disease. Ahmed A, et al. Nanotechnology, 2020 Sep 4. PMID 32045897
    5. pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity. Sofola-Adesakin O, et al. Acta Neuropathol Commun, 2016 Oct 7. PMID 27717375, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4722120-4722001 mobile_element_type = transposon:INE-1{}4487

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metallopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sperm competition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neprilysin 2
    Names
    CG9761-PA
    CG9761-PB
    CG9761-PC
    Nep2-PA
    Nep2-PB
    Nep2-PC
    neprilysin-2
    NP_001246914.1
    NP_001262260.1
    NP_524227.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4719458..4731878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275331.1 → NP_001262260.1  neprilysin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692
      Conserved Domains (2) summary
      cd08662
      Location:104 → 761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:92 → 763
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_079503.4 → NP_524227.1  neprilysin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692
      Related
      FBpp0078531
      Conserved Domains (2) summary
      cd08662
      Location:104 → 761
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:92 → 763
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    3. NM_001259985.2 → NP_001246914.1  neprilysin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246914.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K692, D3DMK4, Q9XZ01
      Conserved Domains (1) summary
      cd08662
      Location:104 → 772
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K692.1 A0A0B4K692

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