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    PEK pancreatic eIF-2alpha kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEKprovided by FlyBase
    Official Full Name
    pancreatic eIF-2alpha kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037327
    Locus tag
    Dmel_CG2087
    See related
    AllianceGenome:FB:FBgn0037327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2087; Dmel\CG2087; DmPEK; dpERK; dPerk; dPERK; DpERK; DPERK; pek; Pek; PEK1; perk; pERK; Perk; PERK
    Summary
    Enables eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including PERK-mediated unfolded protein response; positive regulation of JNK cascade; and regulation of G2/M transition of mitotic cell cycle. Is active in endoplasmic reticulum. Is expressed in several structures, including adult head; larval muscle cell; larval muscle system; and visceral muscle primordium. Human ortholog(s) of this gene implicated in Wolcott-Rallison syndrome and type 1 diabetes mellitus. Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PEK in Genome Data Viewer
    Location:
    83A4-83A4; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5458563..5464753, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1284285..1290475, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Odorant receptor co-receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L35A Neighboring gene Polymerase (DNA-directed), delta interacting protein 2 Neighboring gene mitochondrial ribosomal protein L44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress. Thomas SE, et al. J Biol Chem, 2013 Mar 15. PMID 23341460, Free PMC Article
    2. PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila. Elvira R, et al. Int J Mol Sci, 2020 Jan 28. PMID 32013014, Free PMC Article
    3. Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK. Ly S, et al. Curr Biol, 2020 May 4. PMID 32169212, Free PMC Article
    4. Overexpressed PERK suppresses the neurodegenerative phenotypes in PINK1(B9) flies by enhancing mitochondrial function. Cui Y, et al. Neurochem Int, 2020 Nov. PMID 32898622
    5. Drosophila models of prionopathies: insight into prion protein function, transmission, and neurotoxicity. Fernandez-Funez P, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28415023, Free PMC Article

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
      Title: PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy.
    2. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
      Title: Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
    3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
      Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
    4. The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
      Title: The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
    5. Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
      Title: Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.
    6. Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
      Title: Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways.
    7. PERK-Mediated eIF2alpha Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
      Title: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila.
    8. X-box binding protein 1 overexpression at an early stage reversed Abeta-induced early death without affecting learning performance in the Abeta42 transgenic flies. PERK activation was determined to only enhance Abeta-induced learning deficits.
      Title: XBP1 and PERK Have Distinct Roles in Aβ-Induced Pathology.
    9. PERK and GCN2 act on FOXO to potentiate FOXO activity which has been implicated in the development and progression of a variety of diseases.
      Title: eIF2α kinases PERK and GCN2 act on FOXO to potentiate FOXO activity.
    10. We show that the PKR-like ER kinase (PERK) integrates both cell-autonomous and non-autonomous endoplasmic reticulum stress stimuli to induce intestinal stem cell proliferation.
      Title: PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in PERK-mediated unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in PERK-mediated unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic eIF-2alpha kinase
    Names
    CG2087-PA
    CG2087-PB
    CG2087-PC
    PEK-PA
    PEK-PB
    PEK-PC
    PERK
    pancreatic eIF2alpha kinase
    protein kinase RNA-like endoplasmic reticulum kinase
    NP_001262282.1
    NP_001262283.1
    NP_649538.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5458563..5464753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141281.3 → NP_649538.1  pancreatic eIF-2alpha kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SX61, Q9NIV1, Q9VNB8
      Related
      FBpp0078417
      Conserved Domains (3) summary
      cd09768
      Location:73 → 401
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      smart00220
      Location:925 → 1118
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:635 → 1113
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001275353.1 → NP_001262282.1  pancreatic eIF-2alpha kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGJ5
      Conserved Domains (3) summary
      cd09768
      Location:21 → 349
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      smart00220
      Location:873 → 1066
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:583 → 1061
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001275354.1 → NP_001262283.1  pancreatic eIF-2alpha kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG56
      Conserved Domains (3) summary
      cd09768
      Location:10 → 338
      Luminal_EIF2AK3; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3
      smart00220
      Location:862 → 1055
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:572 → 1050
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG56 A0A0B4KG56
    A0A0B4KGJ5 A0A0B4KGJ5
    Q9NIV1.2 Q9NIV1

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