CG8036 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG8036provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037607
Locus tag: Dmel_CG8036
See related: AllianceGenome:FB:FBgn0037607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.344; Dmel\CG8036; Transk
Summary: Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be involved in pentose-phosphate shunt, non-oxidative branch. Located in cytosol. Is expressed in several structures, including adult CNS glial cell; brain; embryonic/larval midgut primordium; germline cell; and visceral mesoderm derivative. Orthologous to several human genes including TKT (transketolase) and TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85A5-85A5; 3-48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8667868..8673702)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4493590..4499424)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables thiamine pyrophosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables transketolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transketolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in pentose-phosphate shunt, non-oxidative branch	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: uncharacterized protein

Names: CG8036-PB; CG8036-PC; CG8036-PD; transketolase

NP_649812.2

EC 2.2.1.1

NP_731263.2

EC 2.2.1.1

NP_731264.1

EC 2.2.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8667868..8673702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141555.2 → NP_649812.2 uncharacterized protein Dmel_CG8036, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649812.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHN7

Related

FBpp0081370

Conserved Domains (4) summary

cd07033
Location:324 → 478

TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins

PRK05899
Location:8 → 624

PRK05899; transketolase; Reviewed

cd02012
Location:19 → 270

TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...

pfam02780
Location:496 → 616

Transketolase_C; Transketolase, C-terminal domain
NM_169231.2 → NP_731263.2 uncharacterized protein Dmel_CG8036, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731263.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHN7

Related

FBpp0081371

Conserved Domains (4) summary

cd07033
Location:324 → 478

TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins

PRK05899
Location:8 → 624

PRK05899; transketolase; Reviewed

cd02012
Location:19 → 270

TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...

pfam02780
Location:496 → 616

Transketolase_C; Transketolase, C-terminal domain
NM_169232.2 → NP_731264.1 uncharacterized protein Dmel_CG8036, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731264.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KSU6

Related

FBpp0081372

Conserved Domains (4) summary

cd07033
Location:278 → 432

TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins

PRK05899
Location:1 → 578

PRK05899; transketolase; Reviewed

cd02012
Location:1 → 224

TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...

pfam02780
Location:450 → 570

Transketolase_C; Transketolase, C-terminal domain