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    FBXO11 F-box protein 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FBXO11provided by FlyBase
    Official Full Name
    F-box protein 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0037760
    Locus tag
    Dmel_CG9461
    See related
    AllianceGenome:FB:FBgn0037760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9461; dFBX011; Dmel\CG9461; Fbx011; FBX011; Fbxo11; UBR6
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and regulation of apoptotic process. Located in perinuclear region of cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FBXO11 in Genome Data Viewer
    Location:
    85E9-85E10; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9803486..9809368, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5629208..5635090, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44035 Neighboring gene uncharacterized protein Neighboring gene elongase F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome activity determines pupation timing through the degradation speed of timer molecule Blimp-1. Aly H, et al. Dev Growth Differ, 2018 Oct. PMID 30368781
    2. Inactivation of effector caspases through nondegradative polyubiquitylation. Ditzel M, et al. Mol Cell, 2008 Nov 21. PMID 19026784, Free PMC Article
    3. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Boeynaems S, et al. Sci Rep, 2016 Feb 12. PMID 26869068, Free PMC Article
    4. Silencing by small RNAs is linked to endosomal trafficking. Lee YS, et al. Nat Cell Biol, 2009 Sep. PMID 19684574, Free PMC Article
    5. A machine learning approach for identifying novel cell type-specific transcriptional regulators of myogenesis. Busser BW, et al. PLoS Genet, 2012. PMID 22412381, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box protein 11
    Names
    CG9461-PA
    CG9461-PB
    FBX011 ortholog
    FBXO11-PA
    FBXO11-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9803486..9809368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275512.1 → NP_001262441.1  F-box protein 11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NQY0, Q9VH60
      Conserved Domains (3) summary
      smart00396
      Location:1093 → 1146
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam12937
      Location:370 → 414
      F-box-like; F-box-like
      pfam13229
      Location:735 → 882
      Beta_helix; Right handed beta helix region

    2. NM_141697.2 → NP_649954.1  F-box protein 11, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NQY0, Q9VH60
      Related
      FBpp0081633
      Conserved Domains (3) summary
      smart00396
      Location:1093 → 1146
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam12937
      Location:370 → 414
      F-box-like; F-box-like
      pfam13229
      Location:735 → 882
      Beta_helix; Right handed beta helix region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NQY0 Q6NQY0
    Q9VH60 Q9VH60

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