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    SelR Selenoprotein R [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41309, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SelRprovided by FlyBase
    Official Full Name
    Selenoprotein Rprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267376
    Locus tag
    Dmel_CG6584
    See related
    AllianceGenome:FB:FBgn0267376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE36040; BcDNA:RH61230; CG6584; Dmel\CG6584; dMsrB; EP3340; MsrB; MSRB; selR
    Summary
    Enables peptide-methionine (R)-S-oxide reductase activity and zinc ion binding activity. Involved in actin filament polymerization; axon guidance; and chaeta morphogenesis. Located in cytosol and nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; anterior endoderm; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SelR in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10863355..10868642, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6689077..6694364, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 86D Neighboring gene Formaldehyde dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide. Vanhove AS, et al. PLoS Pathog, 2017 Jun. PMID 28586382, Free PMC Article
    2. Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy. Bai J, et al. Proc Natl Acad Sci U S A, 2020 Feb 25. PMID 32029597, Free PMC Article
    3. In Vivo Effects of Methionine Sulfoxide Reductase Deficiency in Drosophila melanogaster. Bruce L, et al. Antioxidants (Basel), 2018 Nov 1. PMID 30388828, Free PMC Article
    4. Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. Kim HY, et al. BMC Mol Biol, 2006 Mar 16. PMID 16542431, Free PMC Article
    5. Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Shchedrina VA, et al. Mech Ageing Dev, 2009 Jul. PMID 19409408, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    selenoprotein R
    Names
    CG6584-PA
    CG6584-PB
    CG6584-PC
    CG6584-PE
    CG6584-PG
    CG6584-PH
    CG6584-PI
    CG6584-PJ
    EP3340
    SelR-PA
    SelR-PB
    SelR-PC
    SelR-PE
    SelR-PG
    SelR-PH
    SelR-PI
    SelR-PJ
    methionine-R-sulfoxide reductase
    NP_001138036.1
    NP_001247036.1
    NP_650030.1
    NP_731522.1
    NP_731523.1
    NP_731524.1
    NP_731525.2
    NP_996195.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10863355..10868642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206473.4 → NP_996195.1  selenoprotein R, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AJI9
      Conserved Domains (1) summary
      PRK00222
      Location:6 → 133
      PRK00222; methionine sulfoxide reductase B; Provisional

    2. NM_141773.4 → NP_650030.1  selenoprotein R, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AJI9
      Related
      FBpp0081769
      Conserved Domains (1) summary
      PRK00222
      Location:6 → 133
      PRK00222; methionine sulfoxide reductase B; Provisional

    3. NM_169370.4 → NP_731524.1  selenoprotein R, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AKC4
      Related
      FBpp0081768
      Conserved Domains (1) summary
      PRK00222
      Location:6 → 144
      PRK00222; methionine sulfoxide reductase B; Provisional

    4. NM_169368.3 → NP_731522.1  selenoprotein R, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INK9
      Related
      FBpp0081771
      Conserved Domains (1) summary
      PRK00222
      Location:48 → 175
      PRK00222; methionine sulfoxide reductase B; Provisional

    5. NM_169369.3 → NP_731523.1  selenoprotein R, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731523.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2P1, B7Z0V7, Q53XF3, Q8IGC0, Q8IGS8, Q8INK8, Q8INK9, Q8INL0, Q8STJ0, Q9VGV4
      Related
      FBpp0081772
      Conserved Domains (1) summary
      PRK00222
      Location:48 → 186
      PRK00222; methionine sulfoxide reductase B; Provisional

    6. NM_169371.4 → NP_731525.2  selenoprotein R, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731525.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INK9
      Conserved Domains (1) summary
      PRK00222
      Location:6 → 134
      PRK00222; methionine sulfoxide reductase B; Provisional

    7. NM_001144564.3 → NP_001138036.1  selenoprotein R, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1B2AJD1
      Conserved Domains (1) summary
      PRK00222
      Location:6 → 141
      PRK00222; methionine sulfoxide reductase B; Provisional

    8. NM_001260107.2 → NP_001247036.1  selenoprotein R, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMP0
      Conserved Domains (1) summary
      PRK00222
      Location:48 → 176
      PRK00222; methionine sulfoxide reductase B; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DMP0 D3DMP0
    Q8INK9.3 Q8INK9

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