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    Paip2 polyA-binding protein interacting protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paip2provided by FlyBase
    Official Full Name
    polyA-binding protein interacting protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038100
    Locus tag
    Dmel_CG12358
    See related
    AllianceGenome:FB:FBgn0038100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12358; Dmel\CG12358; dPaip2; paip2; PAIP2
    Summary
    Predicted to enable translation repressor activity. Involved in negative regulation of translation and regulation of cell growth. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Paip2 in Genome Data Viewer
    Location:
    87D6-87D7; 3-53 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12980792..12985488)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8806514..8811210)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene yellow-f

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth. Roy G, et al. Mol Cell Biol, 2004 Feb. PMID 14729960, Free PMC Article
    2. PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro. Fukaya T, et al. EMBO J, 2011 Nov 25. PMID 22117217, Free PMC Article
    3. Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila. Kachaev ZM, et al. FEBS Lett, 2019 May. PMID 31001806, Free PMC Article
    4. Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila. Kachaev ZM, et al. Cell Cycle, 2018. PMID 29995569, Free PMC Article
    5. The SXL-UNR corepressor complex uses a PABP-mediated mechanism to inhibit ribosome recruitment to msl-2 mRNA. Duncan KE, et al. Mol Cell, 2009 Nov 25. PMID 19941818

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Paip2 is novel player at stage of mRNA capping & Pol II elongation. Nuclear Paip2 is component of ~300-kDa protein complex. Paip2 interacts with mRNA capping factor and factors of RNA polymerase II (Pol II) transcription initiation and early elongation. Paip2 functionally cooperates with Cbp80 subunit of cap-binding complex, with both proteins ensuring proper Pol II C-terminal domain (CTD) Ser5 phosphorylation at promoter
      Title: Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila.
    2. Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally.
      Title: Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila.
    3. Inhibits cell growth primarily by inhibiting protein synthesis.
      Title: The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA regulatory element binding translation repressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    polyA-binding protein interacting protein 2
    Names
    CG12358-PA
    CG12358-PB
    Paip2-PA
    Paip2-PB
    PolyA-binding protein interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12980792..12985488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275586.1 → NP_001262515.1  polyA-binding protein interacting protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG13
      Conserved Domains (1) summary
      pfam07145
      Location:102 → 117
      PAM2; Ataxin-2 C-terminal region

    2. NM_079610.3 → NP_524334.1  polyA-binding protein interacting protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG13
      Related
      FBpp0082161
      Conserved Domains (1) summary
      pfam07145
      Location:102 → 117
      PAM2; Ataxin-2 C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG13 Q9VG13

    Gene LinkOut

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