B52 B52 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: B52provided by FlyBase
Official Full Name: B52provided by FlyBase
Primary source: FLYBASE:FBgn0004587
Locus tag: Dmel_CG10851
See related: AllianceGenome:FB:FBgn0004587
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: B52/dSRp55; B52/SRp55; CG10851; Dmel\CG10851; dSRp55; E(Dfd); E726; l(3)s2249; MabB52; Rbp8; rrm8; RRM8; RSp55; SR55; SRp55; SRSF6
Summary: Enables mRNA binding activity. Involved in several processes, including defense response to virus; mitotic G1/S transition checkpoint signaling; and regulation of RNA metabolic process. Located in euchromatin; nuclear speck; and polytene chromosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; embryonic brain; and primary neurons. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF4 (serine and arginine rich splicing factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87F7-87F7; 3-54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13661311..13666891)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9487033..9492613)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of Yorkie activity by alternative splicing is required for developmental stability.
Title: Modulation of Yorkie activity by alternative splicing is required for developmental stability.
Loss of B52 increases growth of axon branches. B52 function is also required for Choline acetyltransferase (ChAT ) splicing.
Title: Single neuron transcriptomics identify SRSF/SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing.
B52 overexpression increases cell growth, upregulates myc transcription, and gives rise to flies lacking thoracic bristles.
Title: A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila.
B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
Title: The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.
B52/SRp55 generates 2 isoforms of eyeless differing by an alternative exon encoding a 60-AA insert at the beginning of the paired domain. In normal eye development B52/SRp55 controls eye organogenesis & size by regulating eyeless alternative splicing.
Title: Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless.
The SR proteins dASF/SF2 and B52 caused defects in ommatidia structure, and B52 impaired normal axonal projections of photoreceptors and neurogenesis in visual ganglia.
Title: The SR family proteins B52 and dASF/SF2 modulate development of the Drosophila visual system by regulating specific RNA targets.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G1/S transition checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: B52

Names: B52-PA; B52-PB; B52-PC; B52-PD; B52-PF; B52-PI; B52-PK; B52-PM; B52-PN; B52-PO; CG10851-PA; CG10851-PB; CG10851-PC; CG10851-PD; CG10851-PF; CG10851-PI; CG10851-PK; CG10851-PM; CG10851-PN; CG10851-PO; Monoclonal-antibody-B52; RNA-binding protein 8; Serine/arginine rich protein 55; enhancer of deformed; serine-arginine protein 55; splicing factor B52

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13661311..13666891

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176490.3 → NP_788667.2 B52, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788667.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:115 → 186

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_176494.4 → NP_788671.2 B52, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788671.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C4DHG5

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:120 → 191

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_176491.3 → NP_788668.1 B52, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Related

FBpp0082270

Conserved Domains (3) summary

COG0724
Location:4 → 128

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:120 → 191

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_001014619.3 → NP_001014619.2 B52, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014619.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C4DHG5

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:120 → 191

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_001170133.2 → NP_001163604.1 B52, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163604.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Conserved Domains (3) summary

COG0724
Location:4 → 78

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cl17169
Location:115 → 129

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001170132.2 → NP_001163603.1 B52, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163603.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cl17169
Location:106 → 131

RRM_SF; RNA recognition motif (RRM) superfamily
NM_176492.4 → NP_788669.1 B52, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788669.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Related

FBpp0082271

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cl17169
Location:106 → 131

RRM_SF; RNA recognition motif (RRM) superfamily
NM_176488.3 → NP_788665.1 B52, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788665.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Related

FBpp0082269

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:115 → 186

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
NM_176493.4 → NP_788670.1 B52, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788670.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Related

FBpp0082272

Conserved Domains (3) summary

COG0724
Location:4 → 78

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cl17169
Location:115 → 129

RRM_SF; RNA recognition motif (RRM) superfamily
NM_176489.3 → NP_788666.1 B52, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788666.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P26686

Related

FBpp0082274

Conserved Domains (2) summary

cd12337
Location:5 → 74

RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins

cd12600
Location:115 → 186

RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins