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    AOX4 Aldehyde oxidase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AOX4provided by FlyBase
    Official Full Name
    Aldehyde oxidase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0038350
    Locus tag
    Dmel_CG18516
    See related
    AllianceGenome:FB:FBgn0038350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18516; DmAO4; Dmel\CG18516
    Summary
    Predicted to enable aldehyde oxidase activity. Predicted to be involved in cellular aldehyde metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AOX4 in Genome Data Viewer
    Location:
    88F7-88F8; 3-57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15548628..15552833, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11374350..11378555, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Aldehyde oxidase 2 Neighboring gene Aldehyde oxidase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
    2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
    3. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
    4. Drosophila Relish Activating lncRNA-CR33942 Transcription Facilitates Antimicrobial Peptide Expression in Imd Innate Immune Response. Zhou H, et al. Front Immunol, 2022. PMID 35720331, Free PMC Article
    5. Identification of genes expressed during Drosophila melanogaster gastrulation by using subtractive hybridization. González-Agüero M, et al. Gene, 2005 Jan 31. PMID 15716118

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aldehyde oxidase 4
    Names
    AOX4-PA
    CG18516-PA
    NP_650478.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15548628..15552833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142221.2 → NP_650478.1  aldehyde oxidase 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650478.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF50
      Related
      FBpp0082604
      Conserved Domains (6) summary
      smart01008
      Location:542 → 648
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      PLN02906
      Location:24 → 1240
      PLN02906; xanthine dehydrogenase
      pfam00941
      Location:203 → 378
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01799
      Location:80 → 153
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:690 → 1174
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:388 → 489
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF50 Q9VF50

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