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    rec recombination-defective [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    recprovided by FlyBase
    Official Full Name
    recombination-defectiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003227
    Locus tag
    Dmel_CG31293
    See related
    AllianceGenome:FB:FBgn0003227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14875; CG31293; CG4828; Dmel\CG31293; MCM8; Rec; rec-1; rec1
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in reciprocal meiotic recombination. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rec in Genome Data Viewer
    Location:
    89A5-89A5; 3-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15823019..15832632, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11648741..11658354, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45891 Neighboring gene alpha-Mannosidase class II b Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45211 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Time of recombination in the Drosophila melanogaster oocyte: evidence from a temperature-sensitive recombination-deficient mutant. Grell RF. Proc Natl Acad Sci U S A, 1978 Jul. PMID 98767, Free PMC Article
    2. Time of Recombination in the DROSOPHILA MELANOGASTER Oocyte. III. Selection and Characterization of Temperature-Sensitive and -Insensitive, Recombination-Deficient Alleles in Drosophila. Grell RF. Genetics, 1984 Oct. PMID 17246234, Free PMC Article
    3. The meiotic process and aneuploidy. Grell RF. Basic Life Sci, 1985. PMID 4096695
    4. Time of recombination in the Drosophila melanogaster oocyte. II. Electron microscopic and genetic studies of a temperature-sensitive recombination mutant. Grell RF, et al. Chromosoma, 1980. PMID 6778674
    5. MCM proteins in DNA replication. Tye BK. Annu Rev Biochem, 1999. PMID 10872463

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REC drives recombination to repair double-strand breaks in animal mtDNA.
      Title: REC drives recombination to repair double-strand breaks in animal mtDNA.
    2. Mutations that disrupt REC's Walker A and B motifs differentially affect Class I and Class II crossover formation. REC may form multiple complexes that exhibit differential REC-dependent ATP-binding and -hydrolyzing requirements. These results provide genetic insight into the mechanisms through which mei-MCM proteins promote Class I crossovers and inhibit Class II crossovers.
      Title: Meiotic MCM Proteins Promote and Inhibit Crossovers During Meiotic Recombination.
    3. rec gene has no, or only a minor, role in DNA repair and recombination in somatic cells
      Title: REC, a new member of the MCM-related protein family, is required for meiotic recombination in Drosophila.
    4. REC facilitates repair synthesis during meiotic recombination
      Title: REC, Drosophila MCM8, drives formation of meiotic crossovers.
    5. Essential for DNA replication
      Title: REC, Drosophila MCM8, drives formation of meiotic crossovers.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    recombination-defective
    Names
    CG31293-PA
    CG31293-PB
    mini-chromosome maintenance 8
    rec-PA
    rec-PB
    recombination defective

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15823019..15832632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169674.2 → NP_732072.1  recombination-defective, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732072.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VF30
      UniProtKB/TrEMBL
      A0A0B4KH79, T2FGD4
      Related
      FBpp0082647
      Conserved Domains (3) summary
      smart00350
      Location:243 → 792
      MCM; minichromosome maintenance proteins
      cl09939
      Location:117 → 200
      RNR_PFL; Ribonucleotide reductase and Pyruvate formate lyase
      cl21455
      Location:468 → 606
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001275686.1 → NP_001262615.1  recombination-defective, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262615.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VF30
      UniProtKB/TrEMBL
      A0A0B4KH79, T2FGD4
      Conserved Domains (3) summary
      smart00350
      Location:243 → 792
      MCM; minichromosome maintenance proteins
      cl09939
      Location:117 → 200
      RNR_PFL; Ribonucleotide reductase and Pyruvate formate lyase
      cl21455
      Location:468 → 606
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH79 A0A0B4KH79
    Q9VF30.2 Q9VF30

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