NPF neuropeptide F [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NPFprovided by FlyBase
Official Full Name: neuropeptide Fprovided by FlyBase
Primary source: FLYBASE:FBgn0027109
Locus tag: Dmel_CG10342
See related: AllianceGenome:FB:FBgn0027109
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10342; Dm-NPF; Dmel\CG10342; DmNPF; dnpf; dNPF; Drm-NPF; NP-PP; npf; Npf; NPF-A1; NPF-A2; NPF/NPY; NPF89D3; sNPF
Summary: Enables neuropeptide F receptor binding activity and neuropeptide hormone activity. Involved in several processes, including larval feeding behavior; larval foraging behavior; and locomotor rhythm. Located in extracellular region. Is expressed in several structures, including LN period neurons; NPF neuron; epithelial cell; midgut; and protocerebrum. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89D5-89D5; 3-59 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16609220..16611325)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12434942..12437047)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
Title: The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
We find two STIM-regulated peptides, Corazonin and short Neuropeptide F, to be required for NR larvae to complete development. Further, a set of secretory DLP (Dorso lateral peptidergic) neurons which co-express both peptides was identified
Title: ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.
Inhibition of Neuropeptide-F (NPF) activates germline caspases required for transgenerational ethanol preference.
Title: Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression.
The authors found that the homolog of mammalian neuropeptide Y, neuropeptide F (NPF), and a cluster of male-specific NPF (NPF(M)) neurons, regulate courtship through affecting courtship drive.
Title: Neuropeptide F regulates courtship in Drosophila through a male-specific neuronal circuit.
Our results indicate that PDF and sNPF inhibit reproductive dormancy by maintaining the insulin producing cells in an active state.
Title: Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.
the two NPF neurons contribute to appetitive odor induction of impulsive-like feeding by selectively decoding dopamine -encoded ascending olfactory inputs and relaying NPF-encoded descending motivational outputs for behavioral execution.
Title: Two Drosophila Neuropeptide Y-like Neurons Define a Reward Module for Transforming Appetitive Odor Representations to Motivation.
midgut-derived NPF controls mating-induced germline stem cell (GSC) proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs.
Title: Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.
Decreasing autophagy within the mushroom bodies reduced expression of a neuropeptide F, and resulted in impaired associative olfactory memory.
Title: Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.
Flies in which neuropeptide F (NPF) neurons are activated display preference for the illuminated side of the chamber. We show that optogenetic activation of NPF neuron is rewarding in olfactory conditioning experiments and that the preference for NPF neuron activation is dependent on NPF signaling.
Title: Dissection of the Drosophila neuropeptide F circuit using a high-throughput two-choice assay.
NPF-expressing cells, specifically those expressing the circadian photoreceptor cryptochrome, are largely responsible for changes to sleep behavior caused by NPF neuron activation
Title: Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide F receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neuropeptide hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	TAS Traceable Author Statement more info	PubMed
involved_in larval foraging behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	TAS Traceable Author Statement more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multi-organism reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to food	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed