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    EMC2A ER membrane protein complex subunit 2A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC2Aprovided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 2Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038462
    Locus tag
    Dmel_CG17556
    See related
    AllianceGenome:FB:FBgn0038462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17556; Dmel\CG17556; emc2A
    Summary
    Predicted to be part of EMC complex. Is expressed in adult head. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EMC2A in Genome Data Viewer
    Location:
    89E6-89E6; 3-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16994542..16996071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12820264..12821793, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45221 Neighboring gene antisense RNA:CR45213 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3a subunit 1 Neighboring gene Immune-regulated catalase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
    2. The functional domain grouping of microtubule associated proteins. Fisher KH, et al. Commun Integr Biol, 2008. PMID 19704789, Free PMC Article
    3. A microtubule interactome: complexes with roles in cell cycle and mitosis. Hughes JR, et al. PLoS Biol, 2008 Apr 22. PMID 18433294, Free PMC Article
    4. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 2A
    Names
    CG17556-PA
    CG17556-PB
    EMC2A-PA
    EMC2A-PB
    endoplasmic reticulum membrane protein complex 2A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16994542..16996071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142324.2 → NP_650581.1  ER membrane protein complex subunit 2A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZM8, Q9VEQ1
      Related
      FBpp0082818
      Conserved Domains (2) summary
      sd00006
      Location:154 → 181
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:154 → 221
      TPR_11; TPR repeat

    2. NM_001275723.1 → NP_001262652.1  ER membrane protein complex subunit 2A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZM8, Q9VEQ1
      Conserved Domains (2) summary
      sd00006
      Location:154 → 181
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:154 → 221
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXY3 Q8SXY3
    Q8SZM8 Q8SZM8
    Q9VEQ1 Q9VEQ1

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