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    Dys Dystrophin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42327, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dysprovided by FlyBase
    Official Full Name
    Dystrophinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260003
    Locus tag
    Dmel_CG34157
    See related
    AllianceGenome:FB:FBgn0260003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17750; CG31175; CG34157; CG7240; CG7243; CG7344; det; DLP; DLP1; DLP186; DLP2; DLP3; dmDLP; DmDLP; dmDp186; dmDys; DmDYS; Dmel\CG34157; Dp117; Dp186; Dp205; dys; DYS; GI3046716; IDLP
    Summary
    Enables WW domain binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; maintenance of presynaptic active zone structure; and modulation of chemical synaptic transmission. Located in cytoplasm; cytoskeleton; and neuromuscular junction. Part of dystrophin-associated glycoprotein complex. Is expressed in several structures, including brain; germline cell; gut section; imaginal disc; and muscle cell. Used to study Duchenne muscular dystrophy and muscular dystrophy. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to several human genes including UTRN (utrophin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dys in Genome Data Viewer
    Location:
    92A5-92A10; 3-66 cM
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19461085..19597288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15286807..15423010)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinyl-coenzyme A synthetase alpha subunit 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Cuticular protein 92A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables WW domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex HDA PubMed 
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of dystrophin-associated glycoprotein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of dystrophin-associated glycoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dystrophin
    Names
    CG34157-PA
    CG34157-PB
    CG34157-PC
    CG34157-PD
    CG34157-PE
    CG34157-PF
    CG34157-PG
    CG34157-PH
    CG34157-PI
    CG34157-PJ
    CG34157-PK
    CG34157-PL
    Dys-PA
    Dys-PB
    Dys-PC
    Dys-PD
    Dys-PE
    Dys-PF
    Dys-PG
    Dys-PH
    Dys-PI
    Dys-PJ
    Dys-PK
    Dys-PL
    Dystrophin-like protein 1
    Dystrophin-like protein 186
    Dystrophin-like protein 2
    Dystrophin-like protein 3
    detached
    dystrophin Dp186

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19461085..19597288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043263.2NP_001036728.1  dystrophin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDW6
      Conserved Domains (9) summary
      COG0419
      Location:420989
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8481623
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:25092746
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:28842914
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31423190
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:45143
      CH; Calponin homology (CH) domain
      pfam09068
      Location:29153029
      EF-hand_2; EF hand
      pfam09069
      Location:30333132
      EF-hand_3; EF-hand
      cl02488
      Location:13211517
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. NM_001275801.1NP_001262730.1  dystrophin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHR4
      Conserved Domains (10) summary
      smart00150
      Location:19272024
      SPEC; Spectrin repeats
      COG0419
      Location:420989
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8481623
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:21392376
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:25312561
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:27892837
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:45143
      CH; Calponin homology (CH) domain
      pfam09068
      Location:25622676
      EF-hand_2; EF hand
      pfam09069
      Location:26802779
      EF-hand_3; EF-hand
      cl02488
      Location:13211517
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. NM_001275803.1NP_001262732.1  dystrophin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGH0
      Conserved Domains (10) summary
      smart00150
      Location:18951992
      SPEC; Spectrin repeats
      COG0419
      Location:388957
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8161591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:21072344
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:24992529
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:27572805
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:13111
      CH; Calponin homology (CH) domain
      pfam09068
      Location:25302644
      EF-hand_2; EF hand
      pfam09069
      Location:26482747
      EF-hand_3; EF-hand
      cl02488
      Location:12891485
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. NM_001043259.2NP_001036724.1  dystrophin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDW6
      Conserved Domains (10) summary
      smart00150
      Location:18951992
      SPEC; Spectrin repeats
      COG0419
      Location:388957
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8161591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:21072344
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:24822512
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:27402788
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:13111
      CH; Calponin homology (CH) domain
      pfam09068
      Location:25132627
      EF-hand_2; EF hand
      pfam09069
      Location:26312730
      EF-hand_3; EF-hand
      cl02488
      Location:12891485
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    5. NM_001043257.2NP_001036722.1  dystrophin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI51, Q0KI52, Q0KI53, Q9BK96, Q9BK98, Q9BKA0, Q9GT71, Q9VDW4, Q9VDW6
      Conserved Domains (9) summary
      COG0419
      Location:325957
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8161591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:24772714
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:28522882
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31103158
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:13111
      CH; Calponin homology (CH) domain
      pfam09068
      Location:28832997
      EF-hand_2; EF hand
      pfam09069
      Location:30013100
      EF-hand_3; EF-hand
      cl02488
      Location:12891485
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. NM_001043258.2NP_001036723.1  dystrophin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDW6
      Conserved Domains (9) summary
      COG0419
      Location:388957
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8161591
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:24772714
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:28522882
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31103158
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:13111
      CH; Calponin homology (CH) domain
      pfam09068
      Location:28832997
      EF-hand_2; EF hand
      pfam09069
      Location:30013100
      EF-hand_3; EF-hand
      cl02488
      Location:12891485
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    7. NM_001043261.2NP_001036726.1  dystrophin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036726.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDW6
      Conserved Domains (9) summary
      COG0419
      Location:395964
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:8231598
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:24842721
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:28592889
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:31173165
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00307
      Location:20118
      CH; Calponin homology (CH) domain
      pfam09068
      Location:28903004
      EF-hand_2; EF hand
      pfam09069
      Location:30083107
      EF-hand_3; EF-hand
      cl02488
      Location:12961492
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. NM_001275804.1NP_001262733.1  dystrophin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGB9
      Conserved Domains (8) summary
      smart00150
      Location:74171
      SPEC; Spectrin repeats
      cd00176
      Location:286523
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:678708
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:936984
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:709823
      EF-hand_2; EF hand
      pfam09069
      Location:827926
      EF-hand_3; EF-hand
      cl02488
      Location:542652
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02600
      Location:11771213
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    9. NM_001043256.2NP_001036721.1  dystrophin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62529, Q9BK99, Q9VDW3
      Conserved Domains (7) summary
      cd00176
      Location:649886
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:10241054
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:12821330
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:10551169
      EF-hand_2; EF hand
      pfam09069
      Location:11731272
      EF-hand_3; EF-hand
      cl02488
      Location:888998
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02600
      Location:15231559
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    10. NM_001043260.2NP_001036725.1  dystrophin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI50, Q2VQZ5, Q6IJP4
      Conserved Domains (8) summary
      cd00176
      Location:8701071
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:12091239
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:14671515
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:12401354
      EF-hand_2; EF hand
      pfam09069
      Location:13581457
      EF-hand_3; EF-hand
      pfam11740
      Location:15981669
      KfrA_N; Plasmid replication region DNA-binding N-term
      cl02488
      Location:10731183
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02600
      Location:17081744
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    11. NM_001043262.2NP_001036727.1  dystrophin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU29
      Conserved Domains (7) summary
      cd00201
      Location:406436
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:664712
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:437551
      EF-hand_2; EF hand
      pfam09069
      Location:555654
      EF-hand_3; EF-hand
      pfam11740
      Location:795866
      KfrA_N; Plasmid replication region DNA-binding N-term
      cl02488
      Location:270380
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02600
      Location:905941
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
    12. NM_001275802.1NP_001262731.1  dystrophin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHE2
      Conserved Domains (7) summary
      cd00201
      Location:406436
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:664712
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:437551
      EF-hand_2; EF hand
      pfam09069
      Location:555654
      EF-hand_3; EF-hand
      pfam11740
      Location:795866
      KfrA_N; Plasmid replication region DNA-binding N-term
      cl02488
      Location:270380
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl02600
      Location:905941
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily